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Antibiotic resistan...
Antibiotic resistance and its cost : is it possible to reverse resistance?
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- Andersson, Dan I. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Hughes, Diarmaid, 1956- (author)
- Uppsala universitet,Mikrobiologi
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(creator_code:org_t)
- 2010-03-08
- 2010
- English.
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In: Nature Reviews Microbiology. - : Springer Science and Business Media LLC. - 1740-1526 .- 1740-1534. ; 8:4, s. 260-271
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Most antibiotic resistance mechanisms are associated with a fitness cost that is typically observed as a reduced bacterial growth rate. The magnitude of this cost is the main biological parameter that influences the rate of development of resistance, the stability of the resistance and the rate at which the resistance might decrease if antibiotic use were reduced. These findings suggest that the fitness costs of resistance will allow susceptible bacteria to outcompete resistant bacteria if the selective pressure from antibiotics is reduced. Unfortunately, the available data suggest that the rate of reversibility will be slow at the community level. Here, we review the factors that influence the fitness costs of antibiotic resistance, the ways by which bacteria can reduce these costs and the possibility of exploiting them.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Microbiology
- Mikrobiologi
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