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  • Alkner, SaraDepartment of Oncology, Faculty of Medicine, Institute of Clinical Sciences Lund, Lund University, Lund, Sweden; Skåne University Hospital Lund, Department of Hematology, Oncology and Radiation Physics, Lund, Sweden (författare)

Quality assessment of radiotherapy in the prospective randomized SENOMAC trial

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • 2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-226945
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-226945URI
  • https://doi.org/10.1016/j.radonc.2024.110372DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background and purpose: Recommendations for regional radiotherapy (RT) of sentinel lymph node (SLN)-positive breast cancer are debated. We here report a RT quality assessment of the SENOMAC trial.Materials and Methods: The SENOMAC trial randomized clinically node-negative breast cancer patients with 1–2 SLN macrometastases to completion axillary lymph node dissection (cALND) or SLN biopsy only between 2015–2021. Adjuvant RT followed national guidelines. RT plans for patients included in Sweden and Denmark until June 2019 were collected (N = 1176) and compared to case report forms (CRF). Dose to level I (N = 270) and the humeral head (N = 321) was analyzed in detail.Results: CRF-data and RT plans agreed in 99.3 % (breast/chest wall) and in 96.6 % of patients (regional RT). Congruence for whether level I was an intended RT target was lower (78 %). In accordance with Danish national guidelines, level I was more often an intended target in the SLN biopsy only arm (N = 334/611, 55 %,) than in the cALND arm (N = 174/565, 31 %,). When an intended target, level I received prescribed dose to 100 % (IQR 98–100 %) of the volume. However, even when not an intended target, full dose was delivered to > 80 % of level I (IQR 75–90 %). The intentional inclusion of level I in the target volume more than doubled the dose received by ≥ 50 % of the humeral head.Conclusion: Congruence between CRF data and RT plans was excellent. Level I received a high dose coverage even when not intentionally included in the target. Including level I in target significantly increased dose to the humeral head.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wieslander, ElinoreSkåne University Hospital Lund, Department of Hematology, Oncology and Radiation Physics, Lund, Sweden (författare)
  • Lundstedt, DanDepartment of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden; Department of Oncology at, Sahlgrenska University Hospital, Gothenburg, Sweden (författare)
  • Berg, MartinDepartment of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark (författare)
  • Kristensen, IngridSkåne University Hospital Lund, Department of Hematology, Oncology and Radiation Physics, Lund, Sweden (författare)
  • Andersson, YvetteDepartment of Surgery, Vastmanland Hospital Västerås, Västerås, Sweden; Centre for Clinical Research, Uppsala University and Region Vastmanland, Vastmanland Hospital Västerås, Sweden (författare)
  • Bergkvist, LeifCentre for Clinical Research, Uppsala University and Region Vastmanland, Vastmanland Hospital Västerås, Sweden (författare)
  • Frisell, JanDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Breast Center Karolinska, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden (författare)
  • Olofsson Bagge, RogerSahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden (författare)
  • Sund, MalinUmeå universitet,Institutionen för diagnostik och intervention,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Finland(Swepub:umu)masu0021 (författare)
  • Christiansen, PeerDepartment of Plastic and Breast Surgery, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark (författare)
  • Davide Gentilini, OresteBreast Surgery, IRCCS Ospedale San Raffaele, Milano, Italy; Vita-Salute San Raffaele University, Milano, Italy (författare)
  • Kontos, Michalis1st Department of Surgery, National and Kapodistrian University of Athens, Athens, Greece (författare)
  • Kühn, ThorstenDie Filderklinik, Breast Center, Filderstadt, Germany; Department of Gynecology and Obstetrics, University of Ulm, Germany (författare)
  • Reimer, ToralfDepartment of Obstetrics and Gynecology, University of Rostock, Rostock, Germany (författare)
  • Rydén, LisaDepartment of Oncology, Faculty of Medicine, Institute of Clinical Sciences Lund, Lund University, Lund, Sweden; Skåne University Hospital, Department of Gastroenterology and Surgery, Malmö, Sweden (författare)
  • Filtenborg Tvedskov, ToveFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Breast Surgery, Gentofte Hospital, Gentofte, Denmark (författare)
  • Vrou Offersen, BirgitteDepartment of Oncology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark; Department of Experimental Clinical Oncology, Danish Center for Particle Therapy, Aarhus, Denmark (författare)
  • Dahl Nissen, HenrikDepartment of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark (författare)
  • de Boniface, JanaDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Surgery, Capio St. Goran's Hospital, Stockholm, Sweden (författare)
  • Department of Oncology, Faculty of Medicine, Institute of Clinical Sciences Lund, Lund University, Lund, Sweden; Skåne University Hospital Lund, Department of Hematology, Oncology and Radiation Physics, Lund, SwedenSkåne University Hospital Lund, Department of Hematology, Oncology and Radiation Physics, Lund, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Radiotherapy and Oncology1970167-81401879-0887

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