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Chromogranin B in H...
Chromogranin B in Heart Failure : a Putative Cardiac Biomarker Expressed in the Failing Myocardium
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Røsjø, Helge (author)
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Husberg, Cathrine (author)
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Dahl, Mai Britt (author)
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- Stridsberg, Mats (author)
- Uppsala universitet,Biokemisk endokrinologi,Klinisk Kemi
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Sjaastad, Ivar (author)
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Finsen, Alexandra Vanessa (author)
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Carlson, Cathrine Rein (author)
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Øie, Erik (author)
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Omland, Torbjørn (author)
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Christensen, Geir (author)
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Circulation Heart Failure. - 1941-3289 .- 1941-3297. ; 3:4, s. 503-511
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BackgroundChromogranin B (CgB) is a member of the granin protein family. Because CgB is often colocalized with chromogranin A (CgA), a recently discovered cardiac biomarker, we hypothesized that CgB is regulated during heart failure (HF) development.Methods and ResultsCgB regulation was investigated in patients with chronic HF and in a post–myocardial infarction HF mouse model. Animals were phenotypically characterized by echocardiography and euthanized 1 week after myocardial infarction. CgB mRNA levels were 5.2-fold increased in the noninfarcted part of the left ventricle of HF animals compared with sham-operated animals (P<0.001). CgB mRNA level in HF animals correlated closely with animal lung weight (r=0.74, P=0.04) but not with CgA mRNA levels (r=0.20, P=0.61). CgB protein levels were markedly increased in both the noninfarcted (110%) and the infarcted part of the left ventricle (70%) but unaltered in other tissues investigated. Myocardial CgB immunoreactivity was confined to cardiomyocytes. Norepinephrine, angiotensin II, and transforming growth factor-β increased CgB gene expression in cardiomyocytes. Circulating CgB levels were increased in HF animals (median levels in HF animals versus sham, 1.23 [interquartile range, 1.03 to 1.93] versus 0.98 [0.90 to 1.04] nmol/L; P=0.003) and in HF patients (HF patients versus control, 1.66 [1.48 to 1.85] versus 1.47 [1.39 to 1.58] nmol/L; P=0.007), with levels increasing in proportion to New York Heart Association functional class (P=0.03 for trend). Circulating CgB levels were only modestly correlated with CgA (r=0.31, P=0.009) and B-type natriuretic peptide levels (r=0.27, P=0.014).ConclusionsCgB production is increased and regulated in proportion to disease severity in the left ventricle and circulation during HF development.
Keyword
- heart failure
- molecular biology
- biological markers
- chromogranin B
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Røsjø, Helge
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Husberg, Cathrin ...
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Dahl, Mai Britt
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Stridsberg, Mats
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Sjaastad, Ivar
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Finsen, Alexandr ...
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show more...
-
Carlson, Cathrin ...
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Øie, Erik
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Omland, Torbjørn
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Christensen, Gei ...
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Circulation Hear ...
- By the university
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Uppsala University