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Alpha Terpineol :
Alpha Terpineol : A Potential Anticancer Agent which Acts through Suppressing NF-kappa B Signalling
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- Hassan, Saadia Bashir (författare)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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Gali-Muhtasib, Hala (författare)
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- Göransson, Hanna (författare)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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visa fler...
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- Larsson, Rolf (författare)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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visa färre...
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(creator_code:org_t)
- 2010
- 2010
- Engelska.
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 30:6, s. 1911-1919
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Background: Alpha terpineol is a bioactive component of Salvia libanotica essential oil extract and has shown antitumour activity. Materials and Methods: The cytotoxicity of alpha terpineol towards different tumour cell lines was evaluated in vitro. Mechanistic characterization was performed using analysis of drug activity in a cell line panel and drug-induced gene expression perturbation using the connectivity map approach. Results: The small cell lung carcinoma was the cell line most sensitive to alpha terpineol. The results proposed alpha terpineol as an NF-kappa B inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappa B translocation and activity using two NF-kappa B assays, and by the down-regulation of the expression of several NE-kappa B-related genes such as IL-1 beta and IL1R1. Conclusion: The results suggest that alpha terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappa B pathway.
Nyckelord
- Alpha terpineol
- Salvia libanotica
- NF-kappa B
- connectivity map
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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