Sökning: onr:"swepub:oai:DiVA.org:uu-136017" > Twelve type 2 diabe...
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000 | 09485naa a2202281 4500 | |
001 | oai:DiVA.org:uu-136017 | |
003 | SwePub | |
008 | 101209s2010 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:e894a89f-634c-424a-9b8f-4eb5fe7a0c1e | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1360172 URI |
024 | 7 | a https://doi.org/10.1038/ng.6092 DOI |
024 | 7 | a https://lup.lub.lu.se/record/16288032 URI |
040 | a (SwePub)uud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Voight, Benjamin F.4 aut |
245 | 1 0 | a Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis |
264 | c 2010-06-27 | |
264 | 1 | b Springer Science and Business Media LLC,c 2010 |
338 | a print2 rdacarrier | |
520 | a By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 x 10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Scott, Laura J.4 aut |
700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
700 | 1 | a Morris, Andrew P.4 aut |
700 | 1 | a Dina, Christian4 aut |
700 | 1 | a Welch, Ryan P.4 aut |
700 | 1 | a Zeggini, Eleftheria4 aut |
700 | 1 | a Huth, Cornelia4 aut |
700 | 1 | a Aulchenko, Yurii S.4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a McCulloch, Laura J.4 aut |
700 | 1 | a Ferreira, Teresa4 aut |
700 | 1 | a Grallert, Harald4 aut |
700 | 1 | a Amin, Najaf4 aut |
700 | 1 | a Wu, Guanming4 aut |
700 | 1 | a Willer, Cristen J.4 aut |
700 | 1 | a Raychaudhuri, Soumya4 aut |
700 | 1 | a McCarroll, Steve A.4 aut |
700 | 1 | a Langenberg, Claudia4 aut |
700 | 1 | a Hofmann, Oliver M.4 aut |
700 | 1 | a Dupuis, Josee4 aut |
700 | 1 | a Qi, Lu4 aut |
700 | 1 | a Segre, Ayellet V.4 aut |
700 | 1 | a van Hoek, Mandy4 aut |
700 | 1 | a Navarro, Pau4 aut |
700 | 1 | a Ardlie, Kristin4 aut |
700 | 1 | a Balkau, Beverley4 aut |
700 | 1 | a Benediktsson, Rafn4 aut |
700 | 1 | a Bennett, Amanda J.4 aut |
700 | 1 | a Blagieva, Roza4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Bonnycastle, Lori L.4 aut |
700 | 1 | a Bostrom, Kristina Bengtsson4 aut |
700 | 1 | a Bravenboer, Bert4 aut |
700 | 1 | a Bumpstead, Suzannah4 aut |
700 | 1 | a Burtt, Noisel P.4 aut |
700 | 1 | a Charpentier, Guillaume4 aut |
700 | 1 | a Chines, Peter S.4 aut |
700 | 1 | a Cornelis, Marilyn4 aut |
700 | 1 | a Couper, David J.4 aut |
700 | 1 | a Crawford, Gabe4 aut |
700 | 1 | a Doney, Alex S. F.4 aut |
700 | 1 | a Elliott, Katherine S.4 aut |
700 | 1 | a Elliott, Amanda L.4 aut |
700 | 1 | a Erdos, Michael R.4 aut |
700 | 1 | a Fox, Caroline S.4 aut |
700 | 1 | a Franklin, Christopher S.4 aut |
700 | 1 | a Ganser, Martha4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Grarup, Niels4 aut |
700 | 1 | a Green, Todd4 aut |
700 | 1 | a Griffin, Simon4 aut |
700 | 1 | a Groves, Christopher J.4 aut |
700 | 1 | a Guiducci, Candace4 aut |
700 | 1 | a Hadjadj, Samy4 aut |
700 | 1 | a Hassanali, Neelam4 aut |
700 | 1 | a Herder, Christian4 aut |
700 | 1 | a Isomaa, Bo4 aut |
700 | 1 | a Jackson, Anne U.4 aut |
700 | 1 | a Johnson, Paul R. V.4 aut |
700 | 1 | a Jorgensen, Torben4 aut |
700 | 1 | a Kao, Wen H. L.4 aut |
700 | 1 | a Klopp, Norman4 aut |
700 | 1 | a Kong, Augustine4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Kuusisto, Johanna4 aut |
700 | 1 | a Lauritzen, Torsten4 aut |
700 | 1 | a Li, Man4 aut |
700 | 1 | a Lieverse, Aloysius4 aut |
700 | 1 | a Lindgren, Cecilia M.4 aut |
700 | 1 | a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly |
700 | 1 | a Marre, Michel4 aut |
700 | 1 | a Meitinger, Thomas4 aut |
700 | 1 | a Midthjell, Kristian4 aut |
700 | 1 | a Morken, Mario A.4 aut |
700 | 1 | a Narisu, Narisu4 aut |
700 | 1 | a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a Owen, Katharine R.4 aut |
700 | 1 | a Payne, Felicity4 aut |
700 | 1 | a Perry, John R. B.4 aut |
700 | 1 | a Petersen, Ann-Kristin4 aut |
700 | 1 | a Platou, Carl4 aut |
700 | 1 | a Proenca, Christine4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Rathmann, Wolfgang4 aut |
700 | 1 | a Rayner, N. William4 aut |
700 | 1 | a Robertson, Neil R.4 aut |
700 | 1 | a Rocheleau, Ghislain4 aut |
700 | 1 | a Roden, Michael4 aut |
700 | 1 | a Sampson, Michael J.4 aut |
700 | 1 | a Saxena, Richa4 aut |
700 | 1 | a Shields, Beverley M.4 aut |
700 | 1 | a Shrader, Peter4 aut |
700 | 1 | a Sigurdsson, Gunnar4 aut |
700 | 1 | a Sparso, Thomas4 aut |
700 | 1 | a Strassburger, Klaus4 aut |
700 | 1 | a Stringham, Heather M.4 aut |
700 | 1 | a Sun, Qi4 aut |
700 | 1 | a Swift, Amy J.4 aut |
700 | 1 | a Thorand, Barbara4 aut |
700 | 1 | a Tichet, Jean4 aut |
700 | 1 | a Tuomi, Tiinamaija4 aut |
700 | 1 | a van Dam, Rob M.4 aut |
700 | 1 | a van Haeften, Timon W.4 aut |
700 | 1 | a van Herpt, Thijs4 aut |
700 | 1 | a van Vliet-Ostaptchouk, Jana V.4 aut |
700 | 1 | a Walters, G. Bragi4 aut |
700 | 1 | a Weedon, Michael N.4 aut |
700 | 1 | a Wijmenga, Cisca4 aut |
700 | 1 | a Witteman, Jacqueline4 aut |
700 | 1 | a Bergman, Richard N.4 aut |
700 | 1 | a Cauchi, Stephane4 aut |
700 | 1 | a Collins, Francis S.4 aut |
700 | 1 | a Gloyn, Anna L.4 aut |
700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)ulfgyll |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Hide, Winston A.4 aut |
700 | 1 | a Hitman, Graham A.4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Hunter, David J.4 aut |
700 | 1 | a Hveem, Kristian4 aut |
700 | 1 | a Laakso, Markku4 aut |
700 | 1 | a Mohlke, Karen L.4 aut |
700 | 1 | a Morris, Andrew D.4 aut |
700 | 1 | a Palmer, Colin N. A.4 aut |
700 | 1 | a Pramstaller, Peter P.4 aut |
700 | 1 | a Rudan, Igor4 aut |
700 | 1 | a Sijbrands, Eric4 aut |
700 | 1 | a Stein, Lincoln D.4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Uitterlinden, Andre4 aut |
700 | 1 | a Walker, Mark4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Watanabe, Richard M.4 aut |
700 | 1 | a Abecasis, Goncalo R.4 aut |
700 | 1 | a Boehm, Bernhard O.4 aut |
700 | 1 | a Campbell, Harry4 aut |
700 | 1 | a Daly, Mark J.4 aut |
700 | 1 | a Hattersley, Andrew T.4 aut |
700 | 1 | a Hu, Frank B.4 aut |
700 | 1 | a Meigs, James B.4 aut |
700 | 1 | a Pankow, James S.4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Wichmann, H-Erich4 aut |
700 | 1 | a Barroso, Ines4 aut |
700 | 1 | a Florez, Jose C.4 aut |
700 | 1 | a Frayling, Timothy M.4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Sladek, Rob4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Wilson, James F.4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Froguel, Philippe4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a McCarthy, Mark I.4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 42:7, s. 579-589q 42:7<579-589x 1061-4036x 1546-1718 |
856 | 4 | u https://cdr.lib.unc.edu/downloads/f1881v03m |
856 | 4 | u http://dx.doi.org/10.1038/ng.609y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-136017 |
856 | 4 8 | u https://doi.org/10.1038/ng.609 |
856 | 4 8 | u https://lup.lub.lu.se/record/1628803 |
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