Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Nilsson Kristian) > (2010-2014) > Twelve type 2 diabe...

Details
MARC

Voight, Benjamin F. (author)

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010-06-27
Springer Science and Business Media LLC,2010
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-136017
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-136017URI
https://doi.org/10.1038/ng.609DOI
https://lup.lub.lu.se/record/1628803URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 x 10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Scott, Laura J. (author)
Steinthorsdottir, Valgerdur (author)
Morris, Andrew P. (author)
Dina, Christian (author)
Welch, Ryan P. (author)
Zeggini, Eleftheria (author)
Huth, Cornelia (author)
Aulchenko, Yurii S. (author)
Thorleifsson, Gudmar (author)
McCulloch, Laura J. (author)
Ferreira, Teresa (author)
Grallert, Harald (author)
Amin, Najaf (author)
Wu, Guanming (author)
Willer, Cristen J. (author)
Raychaudhuri, Soumya (author)
McCarroll, Steve A. (author)
Langenberg, Claudia (author)
Hofmann, Oliver M. (author)
Dupuis, Josee (author)
Qi, Lu (author)
Segre, Ayellet V. (author)
van Hoek, Mandy (author)
Navarro, Pau (author)
Ardlie, Kristin (author)
Balkau, Beverley (author)
Benediktsson, Rafn (author)
Bennett, Amanda J. (author)
Blagieva, Roza (author)
Boerwinkle, Eric (author)
Bonnycastle, Lori L. (author)
Bostrom, Kristina Bengtsson (author)
Bravenboer, Bert (author)
Bumpstead, Suzannah (author)
Burtt, Noisel P. (author)
Charpentier, Guillaume (author)
Chines, Peter S. (author)
Cornelis, Marilyn (author)
Couper, David J. (author)
Crawford, Gabe (author)
Doney, Alex S. F. (author)
Elliott, Katherine S. (author)
Elliott, Amanda L. (author)
Erdos, Michael R. (author)
Fox, Caroline S. (author)
Franklin, Christopher S. (author)
Ganser, Martha (author)
Gieger, Christian (author)
Grarup, Niels (author)
Green, Todd (author)
Griffin, Simon (author)
Groves, Christopher J. (author)
Guiducci, Candace (author)
Hadjadj, Samy (author)
Hassanali, Neelam (author)
Herder, Christian (author)
Isomaa, Bo (author)
Jackson, Anne U. (author)
Johnson, Paul R. V. (author)
Jorgensen, Torben (author)
Kao, Wen H. L. (author)
Klopp, Norman (author)
Kong, Augustine (author)
Kraft, Peter (author)
Kuusisto, Johanna (author)
Lauritzen, Torsten (author)
Li, Man (author)
Lieverse, Aloysius (author)
Lindgren, Cecilia M. (author)
Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly (author)
Marre, Michel (author)
Meitinger, Thomas (author)
Midthjell, Kristian (author)
Morken, Mario A. (author)
Narisu, Narisu (author)
Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
Owen, Katharine R. (author)
Payne, Felicity (author)
Perry, John R. B. (author)
Petersen, Ann-Kristin (author)
Platou, Carl (author)
Proenca, Christine (author)
Prokopenko, Inga (author)
Rathmann, Wolfgang (author)
Rayner, N. William (author)
Robertson, Neil R. (author)
Rocheleau, Ghislain (author)
Roden, Michael (author)
Sampson, Michael J. (author)
Saxena, Richa (author)
Shields, Beverley M. (author)
Shrader, Peter (author)
Sigurdsson, Gunnar (author)
Sparso, Thomas (author)
Strassburger, Klaus (author)
Stringham, Heather M. (author)
Sun, Qi (author)
Swift, Amy J. (author)
Thorand, Barbara (author)
Tichet, Jean (author)
Tuomi, Tiinamaija (author)
van Dam, Rob M. (author)
van Haeften, Timon W. (author)
van Herpt, Thijs (author)
van Vliet-Ostaptchouk, Jana V. (author)
Walters, G. Bragi (author)
Weedon, Michael N. (author)
Wijmenga, Cisca (author)
Witteman, Jacqueline (author)
Bergman, Richard N. (author)
Cauchi, Stephane (author)
Collins, Francis S. (author)
Gloyn, Anna L. (author)
Gyllensten, UlfUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)ulfgyll (author)
Hansen, Torben (author)
Hide, Winston A. (author)
Hitman, Graham A. (author)
Hofman, Albert (author)
Hunter, David J. (author)
Hveem, Kristian (author)
Laakso, Markku (author)
Mohlke, Karen L. (author)
Morris, Andrew D. (author)
Palmer, Colin N. A. (author)
Pramstaller, Peter P. (author)
Rudan, Igor (author)
Sijbrands, Eric (author)
Stein, Lincoln D. (author)
Tuomilehto, Jaakko (author)
Uitterlinden, Andre (author)
Walker, Mark (author)
Wareham, Nicholas J. (author)
Watanabe, Richard M. (author)
Abecasis, Goncalo R. (author)
Boehm, Bernhard O. (author)
Campbell, Harry (author)
Daly, Mark J. (author)
Hattersley, Andrew T. (author)
Hu, Frank B. (author)
Meigs, James B. (author)
Pankow, James S. (author)
Pedersen, Oluf (author)
Wichmann, H-Erich (author)
Barroso, Ines (author)
Florez, Jose C. (author)
Frayling, Timothy M. (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Sladek, Rob (author)
Thorsteinsdottir, Unnur (author)
Wilson, James F. (author)
Illig, Thomas (author)
Froguel, Philippe (author)
van Duijn, Cornelia M. (author)
Stefansson, Kari (author)
Altshuler, David (author)
Boehnke, Michael (author)
McCarthy, Mark I. (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

In:Nature Genetics: Springer Science and Business Media LLC42:7, s. 579-5891061-40361546-1718

Internet link

Find in a library

Nature Genetics (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Voight, Benjamin ...; Scott, Laura J.; Steinthorsdottir ...; Morris, Andrew P ...; Dina, Christian; Welch, Ryan P.; show more...; Zeggini, Elefthe ...; Huth, Cornelia; Aulchenko, Yurii ...; Thorleifsson, Gu ...; McCulloch, Laura ...; Ferreira, Teresa; Grallert, Harald; Amin, Najaf; Wu, Guanming; Willer, Cristen ...; Raychaudhuri, So ...; McCarroll, Steve ...; Langenberg, Clau ...; Hofmann, Oliver ...; Dupuis, Josee; Qi, Lu; Segre, Ayellet V ...; van Hoek, Mandy; Navarro, Pau; Ardlie, Kristin; Balkau, Beverley; Benediktsson, Ra ...; Bennett, Amanda ...; Blagieva, Roza; Boerwinkle, Eric; Bonnycastle, Lor ...; Bostrom, Kristin ...; Bravenboer, Bert; Bumpstead, Suzan ...; Burtt, Noisel P.; Charpentier, Gui ...; Chines, Peter S.; Cornelis, Marily ...; Couper, David J.; Crawford, Gabe; Doney, Alex S. F ...; Elliott, Katheri ...; Elliott, Amanda ...; Erdos, Michael R ...; Fox, Caroline S.; Franklin, Christ ...; Ganser, Martha; Gieger, Christia ...; Grarup, Niels; Green, Todd; Griffin, Simon; Groves, Christop ...; Guiducci, Candac ...; Hadjadj, Samy; Hassanali, Neela ...; Herder, Christia ...; Isomaa, Bo; Jackson, Anne U.; Johnson, Paul R. ...; Jorgensen, Torbe ...; Kao, Wen H. L.; Klopp, Norman; Kong, Augustine; Kraft, Peter; Kuusisto, Johann ...; Lauritzen, Torst ...; Li, Man; Lieverse, Aloysi ...; Lindgren, Cecili ...; Lyssenko, Valeri ...; Marre, Michel; Meitinger, Thoma ...; Midthjell, Krist ...; Morken, Mario A.; Narisu, Narisu; Nilsson, Peter; Owen, Katharine ...; Payne, Felicity; Perry, John R. B ...; Petersen, Ann-Kr ...; Platou, Carl; Proenca, Christi ...; Prokopenko, Inga; Rathmann, Wolfga ...; Rayner, N. Willi ...; Robertson, Neil ...; Rocheleau, Ghisl ...; Roden, Michael; Sampson, Michael ...; Saxena, Richa; Shields, Beverle ...; Shrader, Peter; Sigurdsson, Gunn ...; Sparso, Thomas; Strassburger, Kl ...; Stringham, Heath ...; Sun, Qi; Swift, Amy J.; Thorand, Barbara; Tichet, Jean; Tuomi, Tiinamaij ...; van Dam, Rob M.; van Haeften, Tim ...; van Herpt, Thijs; van Vliet-Ostapt ...; Walters, G. Brag ...; Weedon, Michael ...; Wijmenga, Cisca; Witteman, Jacque ...; Bergman, Richard ...; Cauchi, Stephane; Collins, Francis ...; Gloyn, Anna L.; Gyllensten, Ulf; Hansen, Torben; Hide, Winston A.; Hitman, Graham A ...; Hofman, Albert; Hunter, David J.; Hveem, Kristian; Laakso, Markku; Mohlke, Karen L.; Morris, Andrew D ...; Palmer, Colin N. ...; Pramstaller, Pet ...; Rudan, Igor; Sijbrands, Eric; Stein, Lincoln D ...; Tuomilehto, Jaak ...; Uitterlinden, An ...; Walker, Mark; Wareham, Nichola ...; Watanabe, Richar ...; Abecasis, Goncal ...; Boehm, Bernhard ...; Campbell, Harry; Daly, Mark J.; Hattersley, Andr ...; Hu, Frank B.; Meigs, James B.; Pankow, James S.; Pedersen, Oluf; Wichmann, H-Eric ...; Barroso, Ines; Florez, Jose C.; Frayling, Timoth ...; Groop, Leif; Sladek, Rob; Thorsteinsdottir ...; Wilson, James F.; Illig, Thomas; Froguel, Philipp ...; van Duijn, Corne ...; Stefansson, Kari; Altshuler, David; Boehnke, Michael; McCarthy, Mark I ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Other Clinical M ...

Articles in the publication: Nature Genetics

By the university: Uppsala University; Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se