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Risk factors of new...
Risk factors of new-onset asthma in adults : a population-based international cohort study
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Anto, J. M. (author)
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Sunyer, J. (author)
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Basagana, X. (author)
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Garcia-Esteban, R. (author)
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Cerveri, I. (author)
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de Marco, R. (author)
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Heinrich, J. (author)
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- Janson, Christer (author)
- Uppsala universitet,Lungmedicin och allergologi
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Jarvis, D. (author)
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Kogevinas, M. (author)
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Kuenzli, N. (author)
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Leynaert, B. (author)
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Svanes, C. (author)
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Wjst, M. (author)
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Gislason, T. (author)
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Burney, P. (author)
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(creator_code:org_t)
- 2010-02-04
- 2010
- English.
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In: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 65:8, s. 1021-1030
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- P>Background: The occurrence of new-onset asthma during adulthood is common, but there is insufficient understanding of its determinants including the role of atopy. Objective: To assess the risk factors for the development of new-onset asthma in middle-aged adults and to compare them according to atopy. Methods: A longitudinal analysis of 9175 young adults who participated in two surveys of the European Community Respiratory Health Survey (ECRHS) conducted 9 years apart. Findings: We observed 179 cases of new-onset asthma among 4588 participants who were free of asthma and reported at the beginning of the follow-up that they had never had asthma (4.5 per 1000 person-years). In a logistic regression, the following risk factors were found to increase the risk of new-onset asthma: female gender (OR: 1.97; 95% confidence interval (CI): 1.38,2.81), bronchial hyperresponsiveness (3.25; 2.19,4.83), atopy (1.55;1.08,2.21), FEV1 < 100 % predicted (1.87;1.34,2.62), nasal allergy (1.98;1.39,2.84) and maternal asthma (1.91;1.13;3.21). Obesity, respiratory infections in early life and high-risk occupations increased the risk of new-onset asthma although we had limited power to confirm their role. Among the atopics, total IgE and sensitization to cat were independently related to the risk of new-onset asthma. The proportion of new-onset asthma attributable to atopy varied from 12% to 21%. Conclusion: Adults reporting that they had never had asthma were at a substantial risk of new-onset asthma as a result of multiple independent risk factors including lung function. Atopy explains a small proportion of new-onset adult asthma.
Keyword
- asthma
- atopy
- bronchial hyperresponsiveness
- ECRHS
- environment
- lung function
- respiratory symptoms
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Anto, J. M.
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Sunyer, J.
-
Basagana, X.
-
Garcia-Esteban, ...
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Cerveri, I.
-
de Marco, R.
-
show more...
-
Heinrich, J.
-
Janson, Christer
-
Jarvis, D.
-
Kogevinas, M.
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Kuenzli, N.
-
Leynaert, B.
-
Svanes, C.
-
Wjst, M.
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Gislason, T.
-
Burney, P.
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show less...
- Articles in the publication
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Allergy. Europea ...
- By the university
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Uppsala University