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Pax2 Is Expressed i...
Pax2 Is Expressed in a Subpopulation of Muller Cells in the Central Chick Retina
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- Boije, Henrik (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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- Ring, Henrik (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi
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Lopez-Gallardo, Meritxell (författare)
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Prada, Carmen (författare)
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- Hallböök, Finn (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi
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(creator_code:org_t)
- 2010-04-23
- 2010
- Engelska.
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Ingår i: Developmental Dynamics. - : Wiley. - 1058-8388 .- 1097-0177. ; 239:6, s. 1858-1866
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Muller cells in the chick retina are generally thought to be a homogeneous population. We show that the transcription factor Pax2 is expressed by Muller cells in the central chick retina and its expression was first observed at stage 32 (embryonic day [E] 7.5). Birth-dating indicated that the majority of Pax2-positive Muller cells are generated between stage 29 and 33 (E5.5-E8). At stage 42 (E16), several Muller cell markers, such as Sox2 and 2M6, had reached the peripheral retina, while the Pax2 labeling extended approximately half-way. A similar pattern was maintained in the 6-month-old chicken. Neither the Pax2-positive nor the Pax2-negative Muller cells could be specifically associated to proliferative responses in the retina induced by growth factors or N-methyl-D-aspartate. Pax2 was not detected in Muller cells in mouse, rat, guinea-pig, rabbit, or pig retinas; but the zebrafish retina displayed a similar pattern of central Pax2-expressing Muller cells.
Nyckelord
- avascular
- development
- EdU
- glia
- Muller glia
- regeneration
- Sox2
- zebrafish
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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