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Immune response to ...
Immune response to the 23-valent polysaccharide pneumococcal vaccine after the 7-valent conjugate vaccine in allogeneic stem cell transplant recipients : Results from the EBMT IDWP01 trial
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Cordonnier, Catherine (författare)
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Labopin, Myriam (författare)
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Chesnel, Virginie (författare)
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Ribaud, Patricia (författare)
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De La Camara, Rafael (författare)
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Martino, Rodrigo (författare)
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Ullmann, Andrew J. (författare)
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Parkkali, Terttu (författare)
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Locasciulli, Anna (författare)
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Yakouben, Karima (författare)
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- Pauksens, Karlis (författare)
- Uppsala universitet,Infektionssjukdomar
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Bonnet, Eric (författare)
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Einsele, Hermann (författare)
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Niederwieser, Dietger (författare)
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Apperley, Jane (författare)
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- Ljungman, Per (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 28:15, s. 2730-2734
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The current recommendations for active immunization after stem cell transplant (SCT) include 3 doses of 7-valent pneumococcal conjugate vaccine (PCV7) from 3 months after transplant, followed by a 23-valent polysaccharide pneumococcal vaccine (PPV23). However, until now, the immune response to PPV23 after PCV7 has not been assessed after SCT. In the EBMT IDWP01 trial, 101 patients received 1 dose of PPV23 at 12 or 18 months, both after 3 doses of PCV7. The efficacy of PPV23 was assessed 1 month later and at 24 months after transplant by the pneumococcal serotype 1 and 5 antibody levels. Serotype 1 and 5 are not included in PCV7. Although the geometric mean concentrations were significantly higher 1 month after PPV23, for both antigens, the response rates (>= 0.15 mu g/mL), in the range of 68-94%, were not different between groups independent of the assessment date. One PPV23 dose after 3 PCV7 doses, already known to increase the response to PCV7, also extends the serotype coverage given 12 or 18 months after transplant. (C) 2010 Elsevier Ltd. All rights reserved.
Nyckelord
- Pneumococcal vaccine
- Pneumococcal infection
- Allogeneic stem cell transplantation
- MEDICINE
- MEDICIN
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Cordonnier, Cath ...
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Labopin, Myriam
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Chesnel, Virgini ...
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Ribaud, Patricia
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De La Camara, Ra ...
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Martino, Rodrigo
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visa fler...
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Ullmann, Andrew ...
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Parkkali, Terttu
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Locasciulli, Ann ...
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Yakouben, Karima
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Pauksens, Karlis
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Bonnet, Eric
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Einsele, Hermann
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Niederwieser, Di ...
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Apperley, Jane
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Ljungman, Per
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Vaccine
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Uppsala universitet
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Karolinska Institutet