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Low levels of IgM a...
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de Faire, UlfKarolinska Institutet
(författare)
Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men : Effects on uptake of oxidized LDL in macrophages as a potential mechanism
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Elsevier BV,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-137139
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137139URI
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https://doi.org/10.1016/j.jaut.2009.05.003DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120117133URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective: We here determine the role of IgM antibodies against phosphorylcholine (anti-PC) in prediction of cardiovascular disease (CVD) and on macrophage uptake of Oxidized LDL (OxLDL). Methods: From a screening of 4232 subjects, 60-year-old (2039 men and 2193 women), 211 incident cases of CVD (myocardial infarction, ischemic stroke, or hospitalized angina pectoris) and 633 age- and sex-matched controls were identified through a 5-7 year follow-up. Serum levels of IgM anti-PC was determined by ELISA. Anti-PC was extracted from pooled human IgM and the effect of anti-PC on the uptake of OxLDL was studied by FACScan. Results: Relative risks (RR) with 95% confidence intervals (Cl) by quartiles of anti-PC levels with quartile 4 set as the reference value (RR = 1.0) and adjusted for smoking, BMI, type 11 diabetes, hypercholesterolaemia, and high blood pressure yielded an excess risk for CVD only for those within the lowest quartile of anti-PC values with an RR of 1.37 (CI 0.87-2.16). However, for men stronger associations were noted with increasing multivariately adjusted RRs from quartile 4 to quartile 1. Subjects within quartile I (values below 29.7 U/ml) had a significantly increased RR of 1.96 (Cl 1.09-3.55). Further adjustments for hsCRP gave essentially the same results. No excess risk was noted for women. Specific anti-PC could be extracted from IgM and these antibodies inhibited macrophage uptake of OxLDL Conclusions: Low IgM anti-PC could be a novel risk marker for CVD among men. One possible mechanism could be inhibition of uptake of oxLDL in macrophages.
Ämnesord och genrebeteckningar
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Atherosclerosis
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Innate immunity
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Natural antibodies
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Phosphorylcholine
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Cardiovascular disease
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Su, Jun
(författare)
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Hua, Xiang
(författare)
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Frostegård, AnnaKarolinska Institutet
(författare)
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Halldin, MatsKarolinska Institutet
(författare)
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Hellenius, Mai-LisKarolinska Institutet
(författare)
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Wikström, Max
(författare)
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Dahlbom, IngridUppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall(Swepub:uu)indah020
(författare)
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Grönlund, HansKarolinska Institutet
(författare)
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Frostegård, JohanKarolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för kvinnors och barns hälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Autoimmunity: Elsevier BV34:2, s. 73-790896-84111095-9157
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de Faire, Ulf
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Su, Jun
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Hua, Xiang
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Frostegård, Anna
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Halldin, Mats
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Hellenius, Mai-L ...
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visa fler...
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Wikström, Max
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Dahlbom, Ingrid
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Grönlund, Hans
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Frostegård, Joha ...
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Journal of Autoi ...
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Uppsala universitet
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Karolinska Institutet