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- Falkén, Y.Karolinska Institutet (author)
Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans
- Article/chapterEnglish2010
Publisher, publication year, extent ...
- 2010-01-21
- Wiley,2010
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-137194
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137194URI
- https://doi.org/10.1111/j.1365-2982.2009.01463.xDOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:120410908URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Background Ghrelin is produced by enteroendocrine cells in the gastric mucosa and stimulates gastric emptying in healthy volunteers and patients with gastroparesis in short-term studies. The aim of this study was to evaluate effects of intravenous ghrelin on gastrointestinal motility and glucose homeostasis during a 6-h infusion in humans. Methods Ghrelin (15 pmol kg−1 min−1) or saline was infused intravenously for 360 min after intake of radio-opaque markers, acetaminophen, and lactulose after a standardized breakfast in 12 male volunteers. Gastric emptying, orocecal transit, colonic transit, postprandial plasma concentrations of glucose, insulin, glucagon-like peptide-1 (GLP-1), and peptide YY were assessed. In vitro studies of gastrointestinal muscle contractility were performed. Key Results The gastric emptying rate was faster for ghrelin compared to saline (P = 0.002) with a shorter half-emptying time (50.3 ± 3.9 vs 59.9 ± 4.4 min, P = 0.004). There was no effect of ghrelin on orocecal or colonic transit. Postprandial elevations of plasma glucose, insulin, and GLP-1 occurred 15 min earlier and were higher with ghrelin. The insulinogenic index did not change during ghrelin infusion. Basal in vitro contractility was unaffected by ghrelin. Conclusions & Inferences The effect of a 6-h ghrelin infusion on gastrointestinal motility is limited to the stomach without affecting orocecal or colonic transit. Plasma glucose, insulin, and GLP-1 are elevated postprandially, probably as a result of the hastened gastric emptying. Changes in glucose homeostasis as a consequence of stimulated gastric emptying and hormone release, need to be taken into account in the use of pharmacological stimulants for the treatment of motility disorders.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
- colon
- gastric emptying
- GLP-1
- insulin
- small bowel
- MEDICINE
- MEDICIN
- Medical Science
- Medicinsk vetenskap
Added entries (persons, corporate bodies, meetings, titles ...)
- Hellström, Per M.,1954-Uppsala universitet,Institutionen för medicinska vetenskaper,Gastroenterologi/Hellström(Swepub:uu)perhe742 (author)
- Sanger, G. J. (author)
- Dewit, O. (author)
- Dukes, G. (author)
- Grybäck, P.Karolinska Institutet (author)
- Holst, J. J. (author)
- Näslund, E.Karolinska Institutet (author)
- Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Related titles
- In:Neurogastroenterology and Motility: Wiley22:6, s. e192-e2001350-19251365-2982
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