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  • Crowther-Swanepoel, Dalemari (author)

Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-01-10
  • Springer Science and Business Media LLC,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-137901
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137901URI
  • https://doi.org/10.1038/ng.510DOI
  • https://lup.lub.lu.se/record/1569837URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:120004914URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Broderick, Peter (author)
  • Di Bernardo, Maria Chiara (author)
  • Dobbins, Sara E. (author)
  • Torres, Maria (author)
  • Mansouri, MahmoudUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)maman377 (author)
  • Ruiz-Ponte, Clara (author)
  • Enjuanes, Anna (author)
  • Rosenquist, RichardUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)richrose (author)
  • Carracedo, Angel (author)
  • Jurlander, Jesper (author)
  • Campo, Elias (author)
  • Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-gju (author)
  • Montserrat, Emilio (author)
  • Smedby, Karin E.Karolinska Institutet (author)
  • Dyer, Martin J. S. (author)
  • Matutes, Estella (author)
  • Dearden, Claire (author)
  • Sunter, Nicola J. (author)
  • Hall, Andrew G. (author)
  • Mainou-Fowler, Tryfonia (author)
  • Jackson, Graham H. (author)
  • Summerfield, Geoffrey (author)
  • Harris, Robert J. (author)
  • Pettitt, Andrew R. (author)
  • Allsup, David J. (author)
  • Bailey, James R. (author)
  • Pratt, Guy (author)
  • Pepper, Chris (author)
  • Fegan, Chris (author)
  • Parker, Anton (author)
  • Oscier, David (author)
  • Allan, James M. (author)
  • Catovsky, Daniel (author)
  • Houlston, Richard S. (author)
  • Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:Nature Genetics: Springer Science and Business Media LLC42:2, s. 132-1361061-40361546-1718

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