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Antigen processing ...
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-12-12
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Springer Science and Business Media LLC,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-138776
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-138776URI
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https://doi.org/10.1038/ni.1974DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Peter A van Veelen, Ferry Ossendorp & Cornelis J M Melief contributed equally to this work.
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Cytotoxic T lymphocytes (CTLs) recognize peptides presented by HLA class I molecules on the cell surface. The C terminus of these CTL epitopes is considered to be produced by the proteasome. Here we demonstrate that the cytosolic endopeptidases nardilysin and thimet oligopeptidase (TOP) complemented proteasome activity. Nardilysin and TOP were required, either together or alone, for the generation of a tumor-specific CTL epitope from PRAME, an immunodominant CTL epitope from Epstein-Barr virus protein EBNA3C, and a clinically important epitope from the melanoma protein MART-1. TOP functioned as C-terminal trimming peptidase in antigen processing, and nardilysin contributed to both the C-terminal and N-terminal generation of CTL epitopes. By broadening the antigenic peptide repertoire, nardilysin and TOP strengthen the immune defense against intracellular pathogens and cancer.
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Khan, Selina
(author)
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Seifert, Ulrike
(author)
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Le Gall, Sylvie
(author)
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Chow, K .Martin
(author)
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Paschen, Annette
(author)
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Bres-Vloemans, Sandra A.
(author)
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de Ru, Arnoud
(author)
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van Montfoort, Nadine
(author)
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Franken, Kees L.M.C.
(author)
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Benckhuijsen, Willemien E.
(author)
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Brooks, Jill M.
(author)
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van Hall, Thorbald
(author)
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Ray, Kallol
(author)
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Mulder, Arend
(author)
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Doxiadis, Ilias I. N.
(author)
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van Swieten, Paul F.
(author)
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Overkleeft, Hermen S.
(author)
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Prat, Annik
(author)
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Tomkinson, BirgittaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)bto18995
(author)
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Neefjes, Jacques
(author)
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Kloetzel, Peter M.
(author)
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Rodgers, David W.
(author)
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Hersh, Louis B.
(author)
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Drijfhout, Jan W.
(author)
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van Veelen, Peter A.
(author)
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Ossendorp, Ferry
(author)
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Melief, Cornelis J. M.
(author)
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Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
Related titles
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In:Nature Immunology: Springer Science and Business Media LLC12:1, s. 45-531529-29081529-2916
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Kessler, Jan H.
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Khan, Selina
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Seifert, Ulrike
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Le Gall, Sylvie
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Chow, K .Martin
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Paschen, Annette
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Bres-Vloemans, S ...
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de Ru, Arnoud
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van Montfoort, N ...
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Franken, Kees L. ...
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Benckhuijsen, Wi ...
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Brooks, Jill M.
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van Hall, Thorba ...
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Ray, Kallol
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Mulder, Arend
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Doxiadis, Ilias ...
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van Swieten, Pau ...
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Overkleeft, Herm ...
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Prat, Annik
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Tomkinson, Birgi ...
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Neefjes, Jacques
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Kloetzel, Peter ...
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Rodgers, David W ...
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Hersh, Louis B.
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Drijfhout, Jan W ...
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van Veelen, Pete ...
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Ossendorp, Ferry
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Melief, Cornelis ...
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