A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

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Enciso-Mora, Victor (author)

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

Article/chapterEnglish2010

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2010-10-31
Springer Science and Business Media LLC,2010
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LIBRIS-ID:oai:DiVA.org:uu-139261
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-139261URI
https://doi.org/10.1038/ng.696DOI
https://lup.lub.lu.se/record/1752366URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:121622687URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10−8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10−13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10−8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10−50). These data provide new insight into the pathogenesis of cHL.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Broderick, Peter (author)
Ma, Yussanne (author)
Jarrett, Ruth F. (author)
Hjalgrim, HenrikKarolinska Institutet (author)
Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-khk (author)
van den Berg, Anke (author)
Olver, Bianca (author)
Lloyd, Amy (author)
Dobbins, Sara E. (author)
Lightfoot, Tracy (author)
van Leeuwen, Flora E. (author)
Foersti, Asta (author)
Diepstra, Arjan (author)
Broeks, Annegien (author)
Vijayakrishnan, Jayaram (author)
Shield, Lesley (author)
Lake, Annette (author)
Montgomery, Dorothy (author)
Roman, Eve (author)
Engert, Andreas (author)
von Strandmann, Elke Pogge (author)
Reiners, Katrin S. (author)
Nolte, Ilja M. (author)
Smedby, Karin E.Karolinska Institutet (author)
Adami, Hans-Olov (author)
Russell, Nicola S. (author)
Glimelius, BengtKarolinska Institutet,Uppsala universitet,Enheten för onkologi(Swepub:uu)bengglim (author)
Hamilton-Dutoit, Stephen (author)
de Bruin, Marieke (author)
Ryder, Lars P. (author)
Molin, DanielUppsala universitet,Enheten för onkologi(Swepub:uu)danimoli (author)
Sorensen, Karina Meden (author)
Chang, Ellen T. (author)
Taylor, Malcolm (author)
Cooke, Rosie (author)
Hofstra, Robert (author)
Westers, Helga (author)
van Wezel, Tom (author)
van Eijk, Ronald (author)
Ashworth, Alan (author)
Rostgaard, Klaus (author)
Melbye, Mads (author)
Swerdlow, Anthony J. (author)
Houlston, Richard S. (author)
Karolinska InstitutetAllmänmedicin och klinisk epidemiologi (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC42:12, s. 1126-11301061-40361546-1718

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By the author/editor: Enciso-Mora, Vic ...; Broderick, Peter; Ma, Yussanne; Jarrett, Ruth F.; Hjalgrim, Henrik; Hemminki, Kari; show more...; van den Berg, An ...; Olver, Bianca; Lloyd, Amy; Dobbins, Sara E.; Lightfoot, Tracy; van Leeuwen, Flo ...; Foersti, Asta; Diepstra, Arjan; Broeks, Annegien; Vijayakrishnan, ...; Shield, Lesley; Lake, Annette; Montgomery, Doro ...; Roman, Eve; Engert, Andreas; von Strandmann, ...; Reiners, Katrin ...; Nolte, Ilja M.; Smedby, Karin E.; Adami, Hans-Olov; Russell, Nicola ...; Glimelius, Bengt; Hamilton-Dutoit, ...; de Bruin, Mariek ...; Ryder, Lars P.; Molin, Daniel; Sorensen, Karina ...; Chang, Ellen T.; Taylor, Malcolm; Cooke, Rosie; Hofstra, Robert; Westers, Helga; van Wezel, Tom; van Eijk, Ronald; Ashworth, Alan; Rostgaard, Klaus; Melbye, Mads; Swerdlow, Anthon ...; Houlston, Richar ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

Articles in the publication: Nature Genetics

By the university: Uppsala University; Lund University; Karolinska Institutet

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