Hospitalization for osteoarthritis and prostate cancer specific mortality among Swedish men with prostate cancer

Purpose: To examine the potential role of nonsteroidal anti-inflammatory drugs (NSAIDs) use on prostate cancer (PCa) specific mortality. Methods: We studied the association between hospitalization for osteoarthritis prior to PCa diagnosis, as a surrogate for heavy use of NSAIDs, and PCa specific mortality in a large population of PCa patients in Sweden in 1980-2004. Results: Hospitalization for osteoarthritis before PCa diagnosis was associated to a lower PCa specific mortality (hazard ratio [HR], 0.92; 95% confidence interval [CI], 0.88-0.96), but not to the risk of death from other causes (HR, 1.03; 95% Cl, 0.99-1.08). The association was stronger among younger patients and patients diagnosed in earlier calendar years. Conclusions: Our data demonstrate a modestly decreased PCa specific mortality among PCa patients with hospitalization for osteoarthritis prior to PCa diagnosis, compared to those without such experience. This finding lends support to the hypothesis that NSAIDs use may influence PCa progression.

Valdimarsdottir, UnnurKarolinska Institutet (författare)
Mucci, LoreleiCentre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA (författare)
Sparén, ParKarolinska Institutet (författare)
Ye, WeiminKarolinska Institutet (författare)
Fall, Katja,1971-Uppsala universitet,Institutionen för genetik och patologi,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:oru)kafl (författare)
Karolinska InstitutetCentre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA (creator_code:org_t)

Ingår i:Cancer EpidemiologyOxon, United Kingdom : Elsevier BV34:5, s. 644-6471877-78211877-783X

Av författaren/redakt...: Fang, Fang; Valdimarsdottir, ...; Mucci, Lorelei; Sparén, Par; Ye, Weimin; Fall, Katja, 197 ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Av lärosätet: Uppsala universitet; Örebro universitet; Karolinska Institutet

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