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Relations of biomar...
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Velagaleti, Raghava S.
(författare)
Relations of biomarkers of extracellular matrix remodeling to incident cardiovascular events and mortality
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-139657
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-139657URI
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https://doi.org/10.1161/ATVBAHA.110.208462DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVE-: To evaluate if biomarkers reflecting left ventricular/vascular extracellular matrix remodeling are associated with cardiovascular disease (CVD) and death in the community. METHODS AND RESULTS-: In 922 Framingham Study participants (mean age, 58 years; 56% women), we related circulating concentrations of matrix metalloproteinase-9 (binary variable: detectable versus undetectable), log of tissue inhibitor of matrix metalloproteinase-1, and log of procollagen type III aminoterminal peptide (PIIINP) to incident CVD and death. On follow-up (mean, 9.9 years), 51 deaths and 81 CVD events occurred. Each SD increment of log of tissue inhibitor of matrix metalloproteinase-1 and log-PIIINP was associated with multivariable-adjusted hazards ratios of 1.72 (95% CI, 1.30 to 2.27) and 1.47 (95% CI, 1.11 to 1.96), respectively, for mortality risk. Log-PIIINP concentrations were also associated with CVD risk (hazard ratio [95% CI] per SD, 1.35 [1.05 to 1.74]). Death and CVD incidence rates were 2-fold higher in participants with both biomarkers higher than the median (corresponding hazard ratio [95% CI], 2.78 [1.43 to 5.40] and 1.77 [1.04 to 3.03], respectively) compared with those with either or both less than the median. The inclusion of both biomarkers improved the C-statistic (for predicting mortality) from 0.78 to 0.82 (P=0.03). Matrix metalloproteinase-9 was unrelated to either outcome. CONCLUSION-: Higher circulating tissue inhibitor of matrix metalloproteinase-1 and PIIINP concentrations are associated with mortality, and higher PIIINP is associated with incident CVD, in the community.
Ämnesord och genrebeteckningar
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cardiovascular disease
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extracellular matrix
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left ventricle
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matrix metalloproteinase-9
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procollagen type III amino-terminal peptide
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remodeling
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tissue inhibitor of matrix metalloproteinase-1
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MEDICINE
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MEDICIN
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Internmedicin
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Internal Medicine
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gona, Philimon
(författare)
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Sundström, JohanUppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)johasund
(författare)
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Larson, Martin G.
(författare)
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Siwik, Deborah
(författare)
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Colucci, Wilson S.
(författare)
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Benjamin, Emelia J.
(författare)
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Vasan, Ramachandran S.
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Arteriosclerosis, Thrombosis and Vascular Biology30:11, s. 2283-22881079-56421524-4636
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