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Body mass index and...
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Carlsson, SofiaKarolinska Institutet
(författare)
Body mass index and mortality : is the association explained by genetic factors?
- Artikel/kapitelEngelska2011
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-139878
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-139878URI
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https://doi.org/10.1097/EDE.0b013e3181fce2a2DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121716759URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: Numerous studies have shown that higher body mass index (BMI) is associated with higher mortality. We investigated the extent to which this association might be explained by genetic factors. METHODS: We used data from the Swedish Twin Registry on twins born 1886-1958 who answered a questionnaire in 1969/1970 or 1972 (n = 44,258). Information on mortality from all-causes (n = 14,217), cardiovascular disease (CVD; n = 9009), and coronary heart disease (CHD; n = 3564) was obtained by linkage to the national Causes of Death Registry for the years 1972-2004. The association between BMI and mortality was studied without control for genetic factors in cohort analyses and with control for genetic factors in co-twin control analyses. RESULTS: In cohort analyses, there was a clear dose-response relationship between BMI and mortality. Hazard ratios per 1 unit increase in BMI in subjects with BMI ≥18.5 were 1.05 (95% confidence interval = 1.05-1.06) for all-cause mortality, 1.07 (1.07-1.09) for CVD mortality, and 1.09 (1.08-1.10) for CHD mortality. Similar results were seen in co-twin control analyses of dizygotic twins. However, within monozygotic twins, BMI was associated with death from CHD (OR = 1.06; 1.00-1.12), whereas the association with all-cause mortality (1.01, 0.98-1.04) and CVD mortality (1.02, 0.98-1.06) was weak. CONCLUSIONS: Our findings indicate that there is an association between high BMI and mortality from CHD that is not explained by genetic confounding. However, a large part of the association between BMI and other causes of death may be explained by genes rather than by a causal link between these factors.
Ämnesord och genrebeteckningar
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MEDICINE
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MEDICIN
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Orthopaedics
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Ortopedi
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Andersson, TomasKarolinska Institutet
(författare)
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de Faire, UlfKarolinska Institutet
(författare)
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Lichtenstein, PaulKarolinska Institutet
(författare)
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Michaëlsson, KarlUppsala universitet,Ortopedi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)karlmich
(författare)
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Ahlbom, AndersKarolinska Institutet
(författare)
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Karolinska InstitutetOrtopedi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Epidemiology22:1, s. 98-1031044-39831531-5487
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