Antibodies against citrullinated vimentin in rheumatoid arthritis: Higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides

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MARC

Mathsson, LindaUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Autoimmunitet (author)

Antibodies against citrullinated vimentin in rheumatoid arthritis : Higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides

Article/chapterEnglish2008

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2007
Wiley,2008
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-14031
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14031URI
https://doi.org/10.1002/art.23188DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:116482786URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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OBJECTIVE: The Sa autoantigen can be found in inflamed synovium of patients with rheumatoid arthritis (RA), and at least part of the humoral RA-specific anti-Sa response is directed against citrullinated vimentin. This study was undertaken to evaluate the sensitivity, specificity, and prognostic value of determination of levels of antibodies against modified citrullinated vimentin (anti-MCV) as compared with antibodies against cyclic citrullinated peptides (anti-CCP) in an inception cohort of patients with early RA. METHODS: Clinical data, radiographs, and measurements of levels of anti-MCV and anti-CCP antibodies were obtained in 273 patients with early RA at baseline, after 3 months, and after 1, 2, 3, and 5 years. Autoantibodies were also analyzed in 100 healthy controls. RESULTS: Of the 273 patients, 193 (70.7%) were anti-MCV positive and 158 (57.9%) were anti-CCP positive at the time of diagnosis, with nearly equal specificities (95% and 96%, respectively). Forty (14.7%) were anti-MCV positive only, and 5 (1.8%) were anti-CCP positive only. Anti-MCV-positive and anti-MCV-negative patients had similar disease activity at baseline, but presence of anti-MCV was predictive of subsequent high disease activity and continued radiographic progression. Changes in anti-MCV level showed stronger correlation with changes in clinical parameters than did changes in anti-CCP level. The subgroup of patients who were anti-MCV positive and anti-CCP negative showed a higher rate of radiographic destruction than did patients who were negative for both anti-MCV and anti-CCP. CONCLUSION: These findings show that when patients with early RA are compared with healthy controls, analysis of anti-MCV yields greater sensitivity and unchanged specificity as compared with analysis of anti-CCP. Anti-MCV also appears to perform better than anti-CCP in identifying poor radiographic prognosis in patients with early RA.

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MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Mullazehi, MohammedKarolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Autoimmunitet(Swepub:uu)momul291 (author)
Wick, Marius C (author)
Sjöberg, Olof (author)
van Vollenhoven, RonaldKarolinska Institutet (author)
Klareskog, LarsKarolinska Institutet (author)
Rönnelid, JohanUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Autoimmunitet(Swepub:uu)joharonn (author)
Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi (creator_code:org_t)

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In:Arthritis and Rheumatism: Wiley58:1, s. 36-450004-35911529-0131

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By the author/editor: Mathsson, Linda; Mullazehi, Moham ...; Wick, Marius C; Sjöberg, Olof; van Vollenhoven, ...; Klareskog, Lars; show more...; Rönnelid, Johan; show less...

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