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  • Almqvist, CatarinaKarolinska Institutet (author)

LifeGene - A large prospective population-based study of global relevance

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2010-11-21
  • Stockholm :Springer Science and Business Media LLC,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-140562
  • ISSN:1573-7284
  • 10616/41729hdl
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-140562URI
  • https://doi.org/10.1007/s10654-010-9521-xDOI
  • https://lup.lub.lu.se/record/1790914URI
  • https://gup.ub.gu.se/publication/134325URI
  • http://hdl.handle.net/10616/41729URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45886URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121819106URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-69718URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • authorCount :16
  • Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18-45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants' age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Adami, Hans-OlovKarolinska Institutet (author)
  • Franks, PaulUmeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Medicin(Swepub:umu)pafr0003 (author)
  • Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
  • Ingelsson, ErikKarolinska Institutet (author)
  • Kere, JuhaKarolinska Institutet (author)
  • Lissner, Lauren,1956Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xlisla (author)
  • Litton, Jan-EricKarolinska Institutet (author)
  • Maeurer, MarkusKarolinska Institutet (author)
  • Michaëlsson, Karl,1959-Uppsala universitet,Ortopedi(Swepub:uu)karlmich (author)
  • Palmgren, JuniStockholms universitet,Karolinska Institutet,Matematiska institutionen(Swepub:su)juni (author)
  • Pershagen, GöranKarolinska Institutet (author)
  • Ploner, AlexanderKarolinska Institutet (author)
  • Sullivan, Patrick F. (author)
  • Tybring, GunnelKarolinska Institutet (author)
  • Pedersen, Nancy L. (author)
  • Karolinska InstitutetGenomik, diabetes och endokrinologi (creator_code:org_t)
  • Karolinska Institutet
  • Karolinska Institutet

Related titles

  • In:European Journal of EpidemiologyStockholm : Springer Science and Business Media LLC26:1, s. 67-770393-29901573-7284

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