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Sökning: id:"swepub:oai:DiVA.org:uu-140834" > Persistent Chlamydi...

  • Gislason, Thorarinn (författare)

Persistent Chlamydia pneumonia serology is related to a more rapid decline in lung function in women but not in men

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • 2010-08-25
  • Springer Science and Business Media LLC,2010
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-140834
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-140834URI
  • https://doi.org/10.1186/1471-2466-10-44DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background Chlamydia pneumoniae (C pn) infection causes an acute inflammation in the respiratory system that may become persistent, but little is known about the long-term respiratory effects of C pn infections. Aim: To estimate the long term respiratory effects of C pn with change in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) as a main outcome variable.Methods The study comprised of 1109 subjects (500 men and 609 women, mean age 28 ± 6 years) that participated in the Reykjavik Heart Study of the Young. Spirometry and blood samples for measurements of IgG antibodies for C pn were done at inclusion and at the end of the follow-up period (mean follow-up time 27 ± 4 years).Results Having IgG against C pn at both examinations was significantly associated to a larger decrease in FEV1 (6 mL/year) and FVC (7 mL/year) in women but not in men. In women the association between C pn and larger FEV1 decline was only found in women that smoked at baseline where having C pn IgG was associated with 10 mL/year decline compared to smokers without C pn IgG. These results were still significant after adjustment for age, smoking and change in body weight.Conclusion Our results indicate that persistent C pn serology is related to increased decline in lung function in women but not in men. This effect was, however, primarily found in smoking women. This study is a further indication that the pathophysiological process leading to lung impairment may differ between men and women.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Guðnason, Vilmundur (författare)
  • Benediktsdottir, Bryndis (författare)
  • Olafsson, Isleifur (författare)
  • Thjodleifsson, Bjarni (författare)
  • Aspelund, Thor (författare)
  • Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn (författare)
  • Uppsala universitetLungmedicin och allergologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMC Pulmonary Medicine: Springer Science and Business Media LLC101471-2466

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