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Persistent Chlamydi...
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Gislason, Thorarinn
(författare)
Persistent Chlamydia pneumonia serology is related to a more rapid decline in lung function in women but not in men
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2010-08-25
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Springer Science and Business Media LLC,2010
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-140834
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-140834URI
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https://doi.org/10.1186/1471-2466-10-44DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background Chlamydia pneumoniae (C pn) infection causes an acute inflammation in the respiratory system that may become persistent, but little is known about the long-term respiratory effects of C pn infections. Aim: To estimate the long term respiratory effects of C pn with change in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) as a main outcome variable.Methods The study comprised of 1109 subjects (500 men and 609 women, mean age 28 ± 6 years) that participated in the Reykjavik Heart Study of the Young. Spirometry and blood samples for measurements of IgG antibodies for C pn were done at inclusion and at the end of the follow-up period (mean follow-up time 27 ± 4 years).Results Having IgG against C pn at both examinations was significantly associated to a larger decrease in FEV1 (6 mL/year) and FVC (7 mL/year) in women but not in men. In women the association between C pn and larger FEV1 decline was only found in women that smoked at baseline where having C pn IgG was associated with 10 mL/year decline compared to smokers without C pn IgG. These results were still significant after adjustment for age, smoking and change in body weight.Conclusion Our results indicate that persistent C pn serology is related to increased decline in lung function in women but not in men. This effect was, however, primarily found in smoking women. This study is a further indication that the pathophysiological process leading to lung impairment may differ between men and women.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Guðnason, Vilmundur
(författare)
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Benediktsdottir, Bryndis
(författare)
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Olafsson, Isleifur
(författare)
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Thjodleifsson, Bjarni
(författare)
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Aspelund, Thor
(författare)
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Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn
(författare)
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Uppsala universitetLungmedicin och allergologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:BMC Pulmonary Medicine: Springer Science and Business Media LLC101471-2466
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