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Deep brain stimulat...
Deep brain stimulation in the treatment of depression
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- Blomstedt, Patric (författare)
- Umeå universitet,Neurokirurgi
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- Sjöberg, Rickard L. (författare)
- Umeå universitet,Uppsala universitet,Centrum för klinisk forskning, Västerås,Neurokirurgi
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- Hansson, Maja (författare)
- Umeå universitet,Psykiatri
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- Bodlund, Owe (författare)
- Umeå universitet,Psykiatri
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- Hariz, Marwan I (författare)
- Umeå universitet,Neurokirurgi
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(creator_code:org_t)
- 2010-10-20
- 2011
- Engelska.
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Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 123:1, s. 4-11
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective: To present the technique of deep brain stimulation (DBS) and to evaluate the studies conducted on DBS in the treatment of therapy-refractory major depressive disorder (MDD). Method: A review of the literature on DBS in the treatment of MDD was conducted. Results: The results of DBS in MDD have been presented in 2 case reports and 3 studies of 47 patients operated upon in 5 different target areas. Positive effects have been presented in all studies and side effects have been minor. DBS in the nucleus accumbens resulted in a mean reduction of Hamilton depression rating scale (HDRS) of 36% after 1 year and 30% of the 10 patients achieved remission. DBS in the internal capsule/ventral striatum resulted in a reduction of 44% after 1 year, and at the last evaluation after in mean 2 years, 40% of the 15 patients were in remission. The 20 patients with subcallosal cingulated gyrus DBS had a reduction of HDRS of 52% after 1 year, and 35% were within 1 point from remission or in remission. Conclusion: DBS is a promising treatment for therapy-refractory MDD. The published experience is, however, limited, and the method is at present an experimental therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- deep brain stimulation
- depression
- stereotaxy
- Psychiatry
- Psykiatri
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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