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Two-year follow-up ...
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
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Engler, Henry (författare)
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- Forsberg, Anton (författare)
- Karolinska Institutet
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- Almkvist, Ove (författare)
- Stockholms universitet,Karolinska Institutet,Psykologiska institutionen
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- Blomquist, Gunnar (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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Larsson, Emma (författare)
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- Savitcheva, Irina (författare)
- Uppsala universitet
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Wall, Anders (författare)
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Ringheim, Anna (författare)
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- Långström, Bengt (författare)
- Uppsala universitet,Institutionen för biokemi och organisk kemi
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Nordberg, Agneta (författare)
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(creator_code:org_t)
- 2006-09-29
- 2006
- Engelska.
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Ingår i: Brain. - : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 129:Pt 11, s. 2856-2866
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Beta amyloid is one of the major histopathological hallmarks of Alzheimer's disease. We recently reported in vivo imaging of amyloid in 16 Alzheimer patients, using the PET ligand N-methyl[11C]2-(4'-methylaminophenyl)-6-hydroxy-benzothiazole (PIB). In the present study we rescanned these 16 Alzheimer patients after 2.0 +/- 0.5 years and have described the interval change in amyloid deposition and regional cerebral metabolic rate for glucose (rCMRGlc) at follow-up. Sixteen patients with Alzheimer's disease were re-examined by means of PET, using PIB and 2-[18F]fluoro-2-deoxy-d-glucose (FDG) after 2.0 +/- 0.5 years. The patients were all on cholinesterase inhibitor treatment and five also on treatment with the N-methyl-d-aspartate (NMDA) antagonist memantine. In order to estimate the accuracy of the PET PIB measurements, four additional Alzheimer patients underwent repeated examinations with PIB within 20 days (test-retest). Relative PIB retention in cortical regions differed by 3-7% in the test-retest study. No significant difference in PIB retention was observed between baseline and follow-up while a significant (P < 0.01) 20% decrease in rCMRGlc was observed in cortical brain regions. A significant negative correlation between rCMRGlc and PIB retention was observed in the parietal cortex in the Alzheimer patients at follow-up (r = 0.67, P = 0.009). A non-significant decline in Mini-Mental State Examination (MMSE) score from 24.3 +/- 3.7 (mean +/- standard deviation) to 22.7 +/- 6.1 was measured at follow-up. Five of the Alzheimer patients showed a significant decline in MMSE score of >3 (21.4 +/- 3.5 to 15.6 +/- 3.9, P < 0.01) (AD-progressive) while the rest of the patients were cognitively more stable (MMSE score = 25.6 +/- 3.1 to 25.9 +/- 3.7) (AD-stable) compared with baseline. A positive correlation (P = 0.001) was observed in the parietal cortex between Rey Auditory Verbal Learning (RAVL) test score and rCMRGlc at follow-up while a negative correlation (P = 0.018) was observed between RAVL test and PIB retention in the parietal at follow-up. Relatively stable PIB retention after 2 years of follow-up in patients with mild Alzheimer's disease suggests that amyloid deposition in the brain reaches a plateau by the early clinical stages of Alzheimer's disease and therefore may precede a decline in rCMRGlc and cognition. It appears that anti-amyloid therapies will need to induce a significant decrease in amyloid load in order for PIB PET images to detect a drug effect in Alzheimer patients. FDG imaging may be able to detect a stabilization of cerebral metabolism caused by therapy administered to patients with a clinical diagnosis of Alzheimer's disease.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- Alzheimer's disease
- amyloid
- PET
- PIB
- FDG
- follow-up
- MEDICINE
- MEDICIN
- Psychology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Brain
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- Av författaren/redakt...
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Engler, Henry
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Forsberg, Anton
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Almkvist, Ove
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Blomquist, Gunna ...
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Larsson, Emma
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Savitcheva, Irin ...
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visa fler...
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Wall, Anders
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Ringheim, Anna
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Långström, Bengt
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Nordberg, Agneta
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visa färre...
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Brain
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Uppsala universitet
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Karolinska Institutet
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Stockholms universitet