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  • Simard, Julia F.Karolinska Institutet,Karolinska Institute (author)

Ten years with biologics : to whom do data on effectiveness and safety apply?

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2010-11-16
  • Oxford University Press (OUP),2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-142796
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-142796URI
  • https://doi.org/10.1093/rheumatology/keq326DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45881URI
  • https://lup.lub.lu.se/record/1731857URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121756985URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-64235URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Methods. We identified all adult patients with RA (n = 9612), PsA (n = 1417) and other SpA (n = 1652) initiating a first biologic therapy between 1 January 1999 and 31 December 2008, registered in the Swedish Biologics Register (ARTIS), including information on demographics, disease characteristics and 1-year risk of first-line treatment discontinuation. Results. Over calendar time, measures of disease activity at start declined substantially for all indications, and diminished between first-, second- and third-line therapy starts. One-year risks of first-line therapy discontinuation increased. Switchers to anti-TNF and non-TNF biologics had different comorbidities. Despite < 50% drug retention at 5 years, most patients remained exposed to some biologic. Conclusions. The trends in baseline characteristics and drug retention underscores that any effects of biologics, including comparison between different biologics, must be interpreted in light of the characteristics of the population treated. The observed differences further call for continued vigilance to properly evaluate the safety profiles of biologic treatments as they are currently used. Exposure to multiple biologics presents a challenge for attribution of long-term effects.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Arkema, Elizabeth V.Karolinska Institutet,Lund University (author)
  • Sundström, AndersKarolinska Institutet (author)
  • Geborek, PierreLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-pge (author)
  • Saxne, ToreLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-tsa (author)
  • Baecklund, EvaUppsala universitet,Reumatologi,Uppsala University(Swepub:uu)evaba786 (author)
  • Cöster, LarsÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Länskliniken för Reumatologi i Östergötland(Swepub:liu)larco79 (author)
  • Dackhammar, ChristinaSahlgrens University Hospital (author)
  • Jacobsson, LennartLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)orto-lja (author)
  • Feltelius, NilsMedical Product Agency, Uppsala (author)
  • Lindblad, StaffanKarolinska Institutet,Karolinska Institute (author)
  • Rantapää-Dahlqvist, SolbrittUmeå universitet,Reumatologi,Umea University, Department Med, Rheumatol Unit, University Hospital, Umea, Sweden(Swepub:umu)sora0001 (author)
  • Klareskog, LarsKarolinska Institutet,Karolinska Institute, Karolinska University Hospital, Department Med, Rheumatol Unit, S-17176 Stockholm, Sweden (author)
  • van Vollenhoven, Ronald F.Karolinska Institutet,Karolinska Institute (author)
  • Neovius, MartinKarolinska Institutet,Karolinska Institute (author)
  • Askling, JohanKarolinska Institutet (author)
  • Karolinska InstitutetKarolinska Institute (creator_code:org_t)

Related titles

  • In:Rheumatology: Oxford University Press (OUP)50:1, s. 204-2131462-03241462-0332

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