Sökning: id:"swepub:oai:DiVA.org:uu-142827" >
Long-term survival ...
-
Zhou, WenjingUppsala universitet,Institutionen för kirurgiska vetenskaper
(författare)
Long-term survival of women with basal-like ductal carcinoma in situ of the breast : a population-based cohort study
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
-
2010-11-30
-
Springer Science and Business Media LLC,2010
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-142827
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-142827URI
-
https://doi.org/10.1186/1471-2407-10-653DOI
-
https://lup.lub.lu.se/record/1772829URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Background: Microarray gene-profiling of invasive breast cancer has identified different subtypes including luminal A, luminal B, HER2-overexpressing and basal-like groups. Basal-like invasive breast cancer is associated with a worse prognosis. However, the prognosis of basal-like ductal carcinoma in situ (DCIS) is still unknown. Our aim was to study the prognosis of basal-like DCIS in a large population-based cohort. Methods: All 458 women with a primary DCIS diagnosed between 1986 and 2004, in Uppland and Vastmanland, Sweden were included. TMA blocks were constructed. To classify the DCIS tumors, we used immunohistochemical (IHC) markers (estrogen-, progesterone-, HER2, cytokeratin 5/6 and epidermal growth factor receptor) as a surrogate for the gene expression profiling. The association with prognosis was examined for basal-like DCIS and other subtypes using Kaplan-Meier survival analyses and Cox proportional hazards regression models. Results: IHC data were complete for 392 women. Thirty-two were basal-like (8.2%), 351 were luminal or HER2-positive (89.5%) and 9 unclassified (2.3%). Seventy-six women had a local recurrence of which 34 were invasive. Another 3 women had general metastases as first event. Basal-like DCIS showed a higher risk of local recurrence and invasive recurrence 1.8 (Confidence interval (CI) 95%, 0.8-4.2) and 1.9 (0.7-5.1), respectively. However, the difference was not statistically significant. Also, no statistically significant increased risk was seen for triple-negative or high grade DCIS. Conclusions: Basal-like DCIS showed about a doubled, however not statistically significant risk for local recurrence and developing invasive cancer compared with the other molecular subtypes. Molecular subtyping was a better prognostic parameter than histopathological grade.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji
(författare)
-
Johansson, ChristineUppsala universitet,Institutionen för genetik och patologi
(författare)
-
Amini, Rose-MarieUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)roseamin
(författare)
-
Blomqvist, Carl
(författare)
-
Agbaje, Olorunsola
(författare)
-
Wärnberg, FredrikUppsala universitet,Institutionen för kirurgiska vetenskaper(Swepub:uu)fredwarn
(författare)
-
Uppsala universitetInstitutionen för kirurgiska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:BMC Cancer: Springer Science and Business Media LLC10, s. 653-1471-2407
Internetlänk
Hitta via bibliotek
Till lärosätets databas