SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Morrison Patrick J)
 

Search: WFRF:(Morrison Patrick J) > (2010-2014) > Brief Report :

Brief Report : AIP Mutation in Pituitary Adenomas in the 18th Century and Today

Chahal, Harvinder S. (author)
Stals, Karen (author)
Unterlander, Martina (author)
show more...
Balding, David J. (author)
Thomas, Mark G. (author)
Uppsala universitet,Evolutionsbiologi
Kumar, Ajith V. (author)
Besser, G. Michael (author)
Atkinson, A. Brew (author)
Morrison, Patrick J. (author)
Howlett, Trevor A. (author)
Levy, Miles J. (author)
Orme, Steve M. (author)
Akker, Scott A. (author)
Abel, Richard L. (author)
Grossman, Ashley B. (author)
Burger, Joachim (author)
Ellard, Sian (author)
Korbonits, Marta (author)
show less...
 (creator_code:org_t)
2011
2011
English.
In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 364:1, s. 43-50
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Gigantism results when a growth hormone-secreting pituitary adenoma is present before epiphyseal fusion. In 1909, when Harvey Cushing examined the skeleton of an Irish patient who lived from 1761 to 1783, *RF 1-3* he noted an enlarged pituitary fossa. We extracted DNA from the patient's teeth and identified a germline mutation in the aryl hydrocarbon-interacting protein gene (AIP). Four contemporary Northern Irish families who presented with gigantism, acromegaly, or prolactinoma have the same mutation and haplotype associated with the mutated gene. Using coalescent theory, we infer that these persons share a common ancestor who lived about 57 to 66 generations earlier.

Keyword

MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view