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Exposure to substan...
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Kogevinas, Manolis
(author)
Exposure to substances in the workplace and new-onset asthma : an international prospective population-based study (ECRHS-II)
- Article/chapterEnglish2007
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-14649
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14649URI
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https://doi.org/10.1016/S0140-6736(07)61164-7DOI
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https://gup.ub.gu.se/publication/62886URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background The role of exposure to substances in the workplace in new-onset asthma is not well characterised in population-based studies. We therefore aimed to estimate the relative and attributable risks of new-onset asthma in relation to occupations, work-related exposures, and inhalation accidents. Methods We studied prospectively 6837 participants from 13 countries who previously took part in the European Community Respiratory Health Survey (1990-95) and did not report respiratory symptoms or a history of asthma at the time of the first study. Asthma was assessed by methacholine challenge test and by questionnaire data on asthma symptoms. Exposures were defined by high-risk occupations, an asthma-specific job exposure matrix with additional expert judgment, and through self-report of acute inhalation events. Relative risks for new onset asthma were calculated with log-binomial models adjusted for age, sex, smoking, and study Centre. Findings A significant excess asthma risk was seen after exposure to substances known to cause occupational asthma (Relative risk=1.6, 95% CI 1.1-2.3, p=0.017). Risks were highest for asthma defined by bronchial hyper-reactivity in addition to symptoms (2.4,1.3-4.6, p=0.008). Of common occupations, a significant excess risk of asthma was seen for nursing (2.2,1.3-4.0, p=0.007). Asthma risk was also increased in participants who reported an acute symptomatic inhalation event such as fire, mixing cleaning products, or chemical spills (RR=3.3, 95% CI 1.0-11.1, p=0.051). The population-attributable risk for adult asthma due to occupational exposures ranged from 10% to 25%, equivalent to an incidence of new-onset occupational asthma of 250-300 cases per million people per year. Interpretation Occupational exposures account for a substantial proportion of adult asthma incidence. The increased risk of asthma after inhalation accidents suggests that workers who have such accidents should be monitored closely.
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Zock, Jan-Paul
(author)
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Jarvis, Debbie
(author)
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Kromhout, Hans
(author)
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Lillienberg, Linnea,1942Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xlilli
(author)
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Plana, Estel
(author)
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Radon, Katja
(author)
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Torén, Kjell,1952Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, Department of Internal Medicine,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xtorkj
(author)
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Alliksoo, Ada
(author)
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Benke, Geza
(author)
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Blanc, Paul D
(author)
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Dahlman-Höglund, Anna,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xdannl
(author)
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D'Errico, Angelo
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Héry, Michel
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Kennedy, Susan
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Kunzli, Nino
(author)
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Leynaert, Bénédicte
(author)
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Mirabelli, Maria C
(author)
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Muniozguren, Nerea
(author)
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Norbäck, DanUppsala universitet,Arbets- och miljömedicin,Eva Vingård(Swepub:uu)dagnorba
(author)
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Olivieri, Mario
(author)
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Payo, Félix
(author)
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Villani, Simona
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van Sprundel, Marc
(author)
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Urrutia, Isabel
(author)
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Wieslander, GunillaUppsala universitet,Arbets- och miljömedicin,Eva Vingård(Swepub:uu)guniwies
(author)
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Sunyer, Jordi
(author)
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Antó, Josep M
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
(creator_code:org_t)
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In:The Lancet370:9584, s. 336-3410140-67361474-547X
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Kogevinas, Manol ...
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Zock, Jan-Paul
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Jarvis, Debbie
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Kromhout, Hans
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Lillienberg, Lin ...
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Plana, Estel
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Radon, Katja
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Torén, Kjell, 19 ...
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Alliksoo, Ada
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Benke, Geza
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Blanc, Paul D
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Dahlman-Höglund, ...
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D'Errico, Angelo
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Héry, Michel
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Kennedy, Susan
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Kunzli, Nino
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Leynaert, Bénédi ...
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Mirabelli, Maria ...
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Muniozguren, Ner ...
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Norbäck, Dan
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Olivieri, Mario
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Payo, Félix
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Villani, Simona
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van Sprundel, Ma ...
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Urrutia, Isabel
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Wieslander, Guni ...
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Sunyer, Jordi
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Antó, Josep M
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