Background aEEG/EEG measures in very preterm infants: Relation to physiology and outcome

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Wikström, SverreUppsala universitet,Institutionen för kvinnors och barns hälsa (författare)

Background aEEG/EEG measures in very preterm infants : Relation to physiology and outcome

BokEngelska2011

Förlag, utgivningsår, omfång ...

Uppsala :Acta Universitatis Upsaliensis,2011
74 s.
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:uu-146737
ISBN:9789155480103
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-146737URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:vet swepub-contenttype
Ämneskategori:dok swepub-publicationtype

Serie

Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,1651-6206 ;647

Anmärkningar

The overall aim of this thesis was to characterize single-channel aEEG/EEG, recorded during the first postnatal days in preterm infants, in relation to brain function and two-year outcome. Study I investigated if aEEG/EEG was associated with neonatal brain injury, inflammation and outcome in 16 very preterm (VPT) infants. The interburst interval (IBI) was prolonged, and aEEG amplitudes were lower in infants with brain injury, and in infants developing handicap. Cord blood TNF-α correlated with IBI. Study II investigated inter-rater agreement of visual burst detection, as compared to automated burst detection based on a non-linear energy operator (NLEO) in an EEG data set from 12 extremely preterm (EPT) and 6 VPT infants. The sensitivity of the NLEO was 64 % and 69 % (EPT and VPT infants, respectively) and the specificity 96 % and 88 %. The algorithm was then modified to further improve the accuracy. Study III investigated if arterial carbon dioxide and plasma glucose is associated with EEG continuity. In 247 sets of samples (PaCO2, plasma glucose, IBI) from 32 EPT infants there was a positive association between PaCO2 and IBI; higher PaCO2 was associated with longer IBI. Corrected for carbon dioxide, plasma glucose had a U-shaped association with IBI in infants with good outcome. Study IV investigated the predictive value of aEEG/EEG in 41 EPT and 8 VPT infants. All VPT infants had good outcome. Predictors of outcome in EPT infants included presence or absence of burst-suppression, continuous activity and cyclicity, median IBI and interburst%. Seizures were associated with neonatal brain damage but not with outcome. Improved preterm brain monitoring may in the future be used for early identification of infants at high risk of brain damage and adverse outcome, which may have implications for direction of care and for early intervention.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
Electroencephalography
brain damage
prediction
interburst interval
Neurodevelopmental impairment
Paediatric medicine
Pediatrisk medicin

Biuppslag (personer, institutioner, konferenser, titlar ...)

Hellström-Westas, Lena,ProfessorUppsala universitet,Institutionen för kvinnors och barns hälsa (preses)
Rosén, Ingmar,Professor emDepartment of Clinical Neurophysiology, Lund University Hospital, Sweden (preses)
Whitelaw, Andrew,ProfessorSchool of Clinical Sciences, University of Bristol (opponent)
Uppsala universitetInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Pediatrik

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