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- Mälarstig, AndersKarolinska Institutet (author)
Raised Interleukin-10 is an Indicator of Poor Outcome and Enhanced Systemic Inflammation in Patients with Acute Coronary Syndrome
- Article/chapterEnglish2008
Publisher, publication year, extent ...
- BMJ,2008
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-14758
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14758URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:117020303URI
- https://doi.org/10.1136/hrt.2007.119271DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- OBJECTIVES: To re-evaluate the relation between plasma interleukin-10 (IL-10) concentration at hospital admission and outcome and to investigate the impact of single nucleotide polymorphisms (SNP) in the IL-10 gene in patients with non-ST elevation acute coronary syndrome (ACS). DESIGN: Determination of IL-10 plasma concentrations and genotyping of SNPs in the IL-10 gene in a prospective trial of patients with ACS and in a group of healthy controls. PATIENTS: 3179 patients in the Fragmin and fast revascularisation during InStability in Coronary artery disease II (FRISC II) trial and 393 healthy controls. MAIN OUTCOME MEASURES: Mortality and incidence of myocardial infarction (MI) at 12 months. RESULTS: The median and interquartile ranges of IL-10 were 0.8 (0.5-1.0) pg/ml in healthy controls and 1.1 (0.7-1.9) pg/ml in patients (p<0.001). In patients, IL-10 predicted a crude risk increase of death/MI, with the highest risk observed in the fourth quartile (adjusted odds ratio 1.7 (95% confidence interval 1.2 to 2.3)). Adjustment for common risk indicators, including C-reactive protein and interleukin-6, weakened the association to a non-significant level. The 1170 CC genotype weakly predicted increased plasma concentrations of IL-10 in patients (p = 0.04) and in controls (p = 0.03), which was consistent with the modest association of this variant with coronary disease (p = 0.01). CONCLUSION: In contrast with some previous reports, we conclude that IL-10 reflects a proinflammatory state in patients with ACS and we therefore suggest that IL-10 is as effective a biomarker for the risk prediction of future cardiovascular events as other markers of systemic inflammation.
Subject headings and genre
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Eriksson, PerKarolinska Institutet (author)
- Hamsten, AndersKarolinska Institutet (author)
- Lindahl, Bertil,1957-Uppsala universitet,Institutionen för medicinska vetenskaper,UCR(Swepub:uu)belin227 (author)
- Wallentin, Lars,1943-Uppsala universitet,Institutionen för medicinska vetenskaper,UCR(Swepub:uu)larswall (author)
- Siegbahn, Agneta,1947-Uppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)agsie424 (author)
- Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Related titles
- In:Heart: BMJ94:6, s. 724-91355-60371468-201X
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