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Mutations in riboso...
Mutations in ribosomal proteins L7/L12 perturb EF-G and EF-Tu functons
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- Bilgin, Neş'e (author)
- Uppsala universitet,Institutionen för molekylärbiologi
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- Kirsebom, Leif A (author)
- Uppsala universitet,Institutionen för molekylärbiologi,Kurland
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- Ehrenberg, Måns (author)
- Uppsala universitet,Institutionen för molekylärbiologi
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- Kurland, Charles G (author)
- Uppsala universitet,Institutionen för molekylärbiologi
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(creator_code:org_t)
- Elsevier BV, 1988
- 1988
- English.
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In: Biochimie. - : Elsevier BV. - 0300-9084 .- 1638-6183. ; 70:5, s. 611-618
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In vitro cycling rates of E. coli ribosomes and of elongation factors EF-Tu and EF-G have been obtained and these are compatible with translation rates in vivo. We show that the rate of translocation is faster than 50 s-1 and therefore that the EF-G function is not a rate limiting step in protein synthesis. The in vivo phenotype of some L7/L12 mutants could be accounted for by perturbed EF-Tu as well as EF-G functions. The S12 mutants that we studied were, in contrast, only perturbed in their EF-Tu function, while their EF-G interaction was not impaired in relation to wild type ribosomes.
Keyword
- ribosomal mutants
- in vitro translation
- NATURAL SCIENCES
- NATURVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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