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- Ullmark, GöstaUppsala universitet,Centrum för klinisk forskning, Gävleborg,Ortopedi (author)
Bone regeneration 6 years after impaction bone grafting : A PET analysis
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- 2009-07-08
- Medical Journals Sweden AB,2007
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-14811
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14811URI
- https://doi.org/10.1080/17453670710013681DOI
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- Language:English
- Summary in:English
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- BACKGROUND: Impacted morselized bone allograft in revision total hip arthroplasty for prosthetic loosening has gained widespread clinical use during the last decades. The clinical results are good but little is known about the bone regeneration in the graft. PATIENTS AND METHODS: 5 patients were revised with impaction of morselized frozen allograft and a cemented total hip arthroplasty (THA) due to loosening and osteolysis of a primary THA. We used positron emission tomography ([18F]-fluoride PET) to produce quantitative images of new bone formation in the allograft surrounding the femur stem 6 years after surgery. RESULTS: The 5 patients had previously been analyzed by [18F]-fluoride PET during the first year after surgery (Sörensen et al. 2003). During the first year, bone formation proceeded through the graft layer and reached the cement layer surrounding the femoral stems. The clinical and radiographic results were excellent at 6 years. PET analyses at 6 years showed that the bone metabolism was significantly reduced in most areas of the proximal femur, compared to the elevated activity during the first year after surgery, and also normalized compared to the contralateral healthy femur. Graft bone metabolism distal to the stem tip remained slightly increased. Small patchy areas of increased uptake remained along the proximal femoral stem, probably reflecting small volumes of fibrous healing. INTERPRETATION: The metabolism of the allografted bone had normalized compared to native bone, indicating full regeneration throughout the graft--and a good long-term prognosis for implant fixation.
Subject headings and genre
- MEDICINE
- MEDICIN
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- Sörensen, JensUppsala universitet,Institutionen för medicinska vetenskaper,Enheten för nuklearmedicin och PET(Swepub:uu)jenssore (author)
- Långström, BengtUppsala universitet,Institutionen för biokemi och organisk kemi(Swepub:uu)benglang (author)
- Nilsson, OlleUppsala universitet,Institutionen för kirurgiska vetenskaper,Ortopedi(Swepub:uu)olnil677 (author)
- Uppsala universitetCentrum för klinisk forskning, Gävleborg (creator_code:org_t)
Related titles
- In:Acta Orthopaedica: Medical Journals Sweden AB78:2, s. 201-2051745-36741745-3682
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