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Genome sequence and...
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-09-09
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Springer Science and Business Media LLC,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-148288
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-148288URI
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https://doi.org/10.1038/nature08358DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-18764URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20100525
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Phytophthora infestans is the most destructive pathogen of potato and a model organism for the oomycetes, a distinct lineage of fungus-like eukaryotes that are related to organisms such as brown algae and diatoms. As the agent of the Irish potato famine in the mid-nineteenth century, P. infestans has had a tremendous effect on human history, resulting in famine and population displacement(1). To this day, it affects world agriculture by causing the most destructive disease of potato, the fourth largest food crop and a critical alternative to the major cereal crops for feeding the world's population(1). Current annual worldwide potato crop losses due to late blight are conservatively estimated at $6.7 billion(2). Management of this devastating pathogen is challenged by its remarkable speed of adaptation to control strategies such as genetically resistant cultivars(3,4). Here we report the sequence of the P. infestans genome, which at similar to 240 megabases (Mb) is by far the largest and most complex genome sequenced so far in the chromalveolates. Its expansion results from a proliferation of repetitive DNA accounting for similar to 74% of the genome. Comparison with two other Phytophthora genomes showed rapid turnover and extensive expansion of specific families of secreted disease effector proteins, including many genes that are induced during infection or are predicted to have activities that alter host physiology. These fast-evolving effector genes are localized to highly dynamic and expanded regions of the P. infestans genome. This probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kamoun, Sophien
(author)
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Zody, Michael C.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)miczo266
(author)
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Jiang, Rays H. Y.
(author)
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Handsaker, Robert E.
(author)
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Cano, Liliana M.
(author)
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Grabherr, Manfred
(author)
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Kodira, Chinnappa D.
(author)
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Raffaele, Sylvain
(author)
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Torto-Alalibo, Trudy
(author)
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Bozkurt, Tolga O.
(author)
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Ah-Fong, Audrey M. V.
(author)
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Alvarado, Lucia
(author)
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Anderson, Vicky L.
(author)
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Armstrong, Miles R.
(author)
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Avrova, Anna
(author)
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Baxter, Laura
(author)
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Beynon, Jim
(author)
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Boevink, Petra C.
(author)
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Bollmann, Stephanie R.
(author)
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Bos, Jorunn I. B.
(author)
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Bulone, VincentKTH,Glykovetenskap(Swepub:kth)u13o1auq
(author)
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Cai, Guohong
(author)
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Cakir, Cahid
(author)
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Carrington, James C.
(author)
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Chawner, Megan
(author)
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Conti, Lucio
(author)
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Costanzo, Stefano
(author)
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Ewan, Richard
(author)
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Fahlgren, Noah
(author)
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Fischbach, Michael A.
(author)
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Fugelstad, JohannaKTH,Glykovetenskap(Swepub:kth)u19ifqej
(author)
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Gilroy, Eleanor M.
(author)
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Gnerre, Sante
(author)
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Green, Pamela J.
(author)
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Grenville-Briggs, Laura J.
(author)
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Griffith, John
(author)
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Gruenwald, Niklaus J.
(author)
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Horn, Karolyn
(author)
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Horner, Neil R.
(author)
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Hu, Chia-Hui
(author)
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Huitema, Edgar
(author)
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Jeong, Dong-Hoon
(author)
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Jones, Alexandra M. E.
(author)
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Jones, Jonathan D. G.
(author)
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Jones, Richard W.
(author)
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Karlsson, Elinor K.
(author)
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Kunjeti, Sridhara G.
(author)
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Lamour, Kurt
(author)
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Liu, Zhenyu
(author)
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Ma, LiJun
(author)
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MacLean, Daniel
(author)
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Chibucos, Marcus C.
(author)
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McDonald, Hayes
(author)
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McWalters, Jessica
(author)
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Meijer, Harold J. G.
(author)
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Morgan, William
(author)
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Morris, Paul F.
(author)
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Munro, Carol A.
(author)
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O'Neill, Keith
(author)
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Ospina-Giraldo, Manuel
(author)
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Pinzon, Andres
(author)
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Pritchard, Leighton
(author)
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Ramsahoye, Bernard
(author)
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Ren, Qinghu
(author)
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Restrepo, Silvia
(author)
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Roy, Sourav
(author)
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Sadanandom, Ari
(author)
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Savidor, Alon
(author)
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Schornack, Sebastian
(author)
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Schwartz, David C.
(author)
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Schumann, Ulrike D.
(author)
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Schwessinger, Ben
(author)
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Seyer, Lauren
(author)
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Sharpe, Ted
(author)
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Silvar, Cristina
(author)
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Song, Jing
(author)
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Studholme, David J.
(author)
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Sykes, Sean
(author)
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Thines, Marco
(author)
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van de Vondervoort, Peter J. I.
(author)
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Phuntumart, Vipaporn
(author)
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Wawra, Stephan
(author)
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Weide, Rob
(author)
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Win, Joe
(author)
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Young, Carolyn
(author)
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Zhou, Shiguo
(author)
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Fry, William
(author)
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Meyers, Blake C.
(author)
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van West, Pieter
(author)
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Ristaino, Jean
(author)
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Govers, Francine
(author)
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Birch, Paul R. J.
(author)
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Whisson, Stephen C.
(author)
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Judelson, Howard S.
(author)
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Nusbaum, Chad
(author)
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Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
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In:Nature: Springer Science and Business Media LLC461:7262, s. 393-3980028-08361476-4687
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- By the author/editor
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Haas, Brian J.
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Kamoun, Sophien
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Zody, Michael C.
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Jiang, Rays H. Y ...
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Handsaker, Rober ...
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Cano, Liliana M.
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Grabherr, Manfre ...
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Kodira, Chinnapp ...
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Raffaele, Sylvai ...
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Torto-Alalibo, T ...
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Bozkurt, Tolga O ...
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Ah-Fong, Audrey ...
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Alvarado, Lucia
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Anderson, Vicky ...
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Armstrong, Miles ...
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Avrova, Anna
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Baxter, Laura
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Beynon, Jim
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Boevink, Petra C ...
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Bollmann, Stepha ...
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Bos, Jorunn I. B ...
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Bulone, Vincent
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Cai, Guohong
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Cakir, Cahid
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Carrington, Jame ...
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Chawner, Megan
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Conti, Lucio
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Costanzo, Stefan ...
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Ewan, Richard
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Fahlgren, Noah
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Fischbach, Micha ...
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Fugelstad, Johan ...
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Gilroy, Eleanor ...
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Gnerre, Sante
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Green, Pamela J.
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Grenville-Briggs ...
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Griffith, John
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Gruenwald, Nikla ...
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Horn, Karolyn
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Horner, Neil R.
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Hu, Chia-Hui
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Huitema, Edgar
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Jeong, Dong-Hoon
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Jones, Alexandra ...
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Jones, Jonathan ...
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Jones, Richard W ...
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Karlsson, Elinor ...
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Kunjeti, Sridhar ...
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Lamour, Kurt
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Liu, Zhenyu
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Ma, LiJun
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MacLean, Daniel
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Chibucos, Marcus ...
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McDonald, Hayes
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McWalters, Jessi ...
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Meijer, Harold J ...
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Morgan, William
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Morris, Paul F.
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Munro, Carol A.
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O'Neill, Keith
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Ospina-Giraldo, ...
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Pinzon, Andres
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Pritchard, Leigh ...
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Ramsahoye, Berna ...
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Ren, Qinghu
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Restrepo, Silvia
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Roy, Sourav
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Sadanandom, Ari
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Savidor, Alon
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Schornack, Sebas ...
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Schwartz, David ...
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Schumann, Ulrike ...
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Schwessinger, Be ...
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Seyer, Lauren
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Sharpe, Ted
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Silvar, Cristina
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Song, Jing
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Studholme, David ...
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Sykes, Sean
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Thines, Marco
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van de Vondervoo ...
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Phuntumart, Vipa ...
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Wawra, Stephan
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Weide, Rob
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Win, Joe
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Young, Carolyn
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Zhou, Shiguo
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Fry, William
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Meyers, Blake C.
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van West, Pieter
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Ristaino, Jean
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Birch, Paul R. J ...
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- NATURAL SCIENCES
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