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Chronic Lymphocytic...
Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors : Shared and Distinct Immunogenetic Features and Clinical Outcomes
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- Xochelli, Aliki (författare)
- Uppsala University,Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,CERTH, Inst Appl Biosci, Thessaloniki, Greece,Center for Research and Technology Hellas
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- Baliakas, Panagiotis, 1977- (författare)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi,.
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- Kavakiotis, Ioannis (författare)
- Aristotle Univ Thessaloniki, Dept Informat, Thessaloniki, Greece.,Aristotle University of Thessaloniki
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visa fler...
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- Agathangelidis, Andreas (författare)
- Karolinska Institutet,Center for Research and Technology Hellas,San Raffaele Scientific Institute
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- Sutton, Lesley Ann (författare)
- Uppsala University,Karolinska Institute,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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- Minga, Eva (författare)
- CERTH, Inst Appl Biosci, Thessaloniki, Greece.,Center for Research and Technology Hellas
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- Ntoufa, Stavroula (författare)
- CERTH, Inst Appl Biosci, Thessaloniki, Greece.,Center for Research and Technology Hellas
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- Tausch, Eugen (författare)
- Ulm Univ, Dept Internal Med 3, Ulm, Germany.,University of Ulm
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- Yan, Xiao-Jie (författare)
- Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY USA.,Feinstein Institute for Medical Research
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- Shanafelt, Tait (författare)
- Mayo Clin, Dept Med, Dept Hematol, Rochester, MN USA.,Mayo Clinic Minnesota
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- Plevova, Karla (författare)
- Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic.,Masaryk University
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- Boudjogra, Myriam (författare)
- Hop La Pitie Salpetriere, Dept Hematol, Paris, France.;Univ Paris 06, Paris, France.,Paris-Sorbonne University
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- Rossi, Davide (författare)
- Univ Piemonte Orientale, Dept Translat Med, Dept Haematol, Novara, Italy.,University of Eastern Piedmont
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- Davis, Zadie (författare)
- Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England.,Royal Bournemouth Hospital
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- Navarro, Alba (författare)
- Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Hosp Clin, Barcelona, Spain.,University of Barcelona
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- Sandberg, Yorick (författare)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Immunol, Rotterdam, Netherlands.,Erasmus University Medical Center
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- Vojdeman, Fie Juhl (författare)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
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- Scarfo, Lydia (författare)
- IRCCS San Raffaele Sci Inst, Div Expt Oncol, Milan, Italy.;IRCCS San Raffaele Sci Inst, Dept Oncohematol, Milan, Italy.,San Raffaele Scientific Institute
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- Stavroyianni, Niki (författare)
- G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.,George Papanicolaou General Hospital
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- Sudarikov, Andrey (författare)
- Natl Res Ctr Hematol, Moscow, Russia.,National Research Center for Hematology
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- Veronese, Silvio (författare)
- Osped Niguarda Ca Granda, Mol Pathol Unit, Milan, Italy.;Osped Niguarda Ca Granda, Dept Haematol, Milan, Italy.,Niguarda Hospital
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- Tzenou, Tatiana (författare)
- Univ Athens, Dept Propaedeut Med 1, Athens, Greece.,National and Kapodistrian University of Athens
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- Karan-Djurasevic, Teodora (författare)
- Univ Belgrade, Inst Mol Genet & Genet Engn, Belgrade, Serbia.,University of Belgrade
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- Catherwood, Mark (författare)
- Belfast City Hosp, Dept Haematooncol, Belfast, Antrim, North Ireland.,Belfast City Hospital
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- Kienle, Dirk (författare)
- Ulm Univ, Dept Internal Med 3, Ulm, Germany.,University of Ulm
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- Chatzouli, Maria (författare)
- Nikea Gen Hosp, Dept Hematol, Piraeus, Greece.,Nikea General Hospital, Piraeus
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- Facco, Monica (författare)
- Univ Padua, Sch Med, Hematol & Clin Immunol Branch, Dept Med, Padua, Italy.,University of Padova
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- Bahlo, Jasmin (författare)
- Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany.;Univ Hosp Cologne, Ctr Integrated Oncol, Cologne, Germany.,University Hospital of Cologne
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- Pott, Christiane (författare)
- Univ Hosp Schleswig Holstein, Med Dept 2, Campus Kiel, Kiel, Germany.,University Medical Center Schleswig-Holstein
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- Pedersen, Lone Bredo (författare)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
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- Mansouri, Larry (författare)
- Uppsala University,Karolinska Institute,Karolinska Institutet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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- Smedby, Karin E. (författare)
- Karolinska Institute,Karolinska Institutet
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- Chu, Charles C. (författare)
- Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY USA.,Feinstein Institute for Medical Research
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- Giudicelli, Veronique (författare)
- Univ Montpellier, CNRS, UPR 1142, IMGT,LIGM,IGH, Montpellier, France.,Institut de Génétique Humaine
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- Lefranc, Marie-Paule (författare)
- Univ Montpellier, CNRS, UPR 1142, IMGT,LIGM,IGH, Montpellier, France.,Institut de Génétique Humaine
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- Panagiotidis, Panagiotis (författare)
- Univ Athens, Dept Propaedeut Med 1, Athens, Greece.,National and Kapodistrian University of Athens
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- Juliusson, Gunnar (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Anagnostopoulos, Achilles (författare)
- G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.,George Papanicolaou General Hospital
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- Vlahavas, Ioannis (författare)
- Aristotle Univ Thessaloniki, Dept Informat, Thessaloniki, Greece.,Aristotle University of Thessaloniki
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- Antic, Darko (författare)
- Ctr Clin, Clin Hematol, Belgrade, Serbia.;Univ Belgrade, Fac Med, Belgrade, Serbia.,University of Belgrade
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- Trentin, Livio (författare)
- Univ Padua, Sch Med, Hematol & Clin Immunol Branch, Dept Med, Padua, Italy.,University of Padova
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- Montillo, Marco (författare)
- Osped Niguarda Ca Granda, Mol Pathol Unit, Milan, Italy.;Osped Niguarda Ca Granda, Dept Haematol, Milan, Italy.,Niguarda Hospital
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- Niemann, Carsten (författare)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
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- Doehner, Hartmut (författare)
- Ulm Univ, Dept Internal Med 3, Ulm, Germany.,University of Ulm
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- Langerak, Anton W. (författare)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Immunol, Rotterdam, Netherlands.,Erasmus University Medical Center
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- Pospisilova, Sarka (författare)
- Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic.,Masaryk University
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- Hallek, Michael (författare)
- Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany.;Univ Hosp Cologne, Ctr Integrated Oncol, Cologne, Germany.,University Hospital of Cologne
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- Campo, Elias (författare)
- Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Hosp Clin, Barcelona, Spain.,University of Barcelona
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- Chiorazzi, Nicholas (författare)
- Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY USA.,Feinstein Institute for Medical Research
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- Maglaveras, Nikos (författare)
- Aristotle Univ Thessaloniki, Lab Med Informat, Thessaloniki, Greece.,Aristotle University of Thessaloniki
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- Oscier, David (författare)
- Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England.,Royal Bournemouth Hospital
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- Gaidano, Gianluca (författare)
- Univ Piemonte Orientale, Dept Translat Med, Dept Haematol, Novara, Italy.,University of Eastern Piedmont
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- Jelinek, Diane F. (författare)
- Mayo Clin, Dept Immunol, Rochester, MN USA.,Mayo Clinic Minnesota
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- Stilgenbauer, Stephan (författare)
- Ulm Univ, Dept Internal Med 3, Ulm, Germany.,University of Ulm
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- Chouvarda, Ioanna (författare)
- Aristotle Univ Thessaloniki, Lab Med Informat, Thessaloniki, Greece.,Aristotle University of Thessaloniki
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- Darzentas, Nikos (författare)
- Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic.,Masaryk University
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- Belessi, Chrysoula (författare)
- Nikea Gen Hosp, Dept Hematol, Piraeus, Greece.,Nikea General Hospital, Piraeus
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- Davi, Frederic (författare)
- Hop La Pitie Salpetriere, Dept Hematol, Paris, France.;Univ Paris 06, Paris, France.,Paris-Sorbonne University
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- Hadzidimitriou, Anastasia (författare)
- Uppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,CERTH, Inst Appl Biosci, Thessaloniki, Greece.,Center for Research and Technology Hellas
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- Rosenquist, Richard (författare)
- Uppsala University,Karolinska Institute,Karolinska Institutet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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- Ghia, Paolo (författare)
- IRCCS San Raffaele Sci Inst, Div Expt Oncol, Milan, Italy.;IRCCS San Raffaele Sci Inst, Dept Oncohematol, Milan, Italy.;Univ Vita Salute San Raffaele, Milan, Italy.;IRCCS Ist Sci San Raffaele, Milan, Italy.,Vita-Salute San Raffaele University,San Raffaele Scientific Institute
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- Stamatopoulos, Kostas (författare)
- Uppsala University,Uppsala universitet,Experimentell och klinisk onkologi,CERTH, Inst Appl Biosci, Thessaloniki, Greece ;G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.,George Papanicolaou General Hospital,Center for Research and Technology Hellas
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 23:17, s. 5292-5301
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Purpose: We sought to investigate whether B cell receptor immunoglobulin (BcR IG) stereotypy is associated with particular clinicobiological features among chronic lymphocytic leukemia (CLL) patients expressing mutated BcR IG (M-CLL) encoded by the IGHV4-34 gene, and also ascertain whether these associations could refine prognostication. Experimental Design: In a series of 19,907 CLL cases with available immunogenetic information, we identified 339 IGHV4-34expressing cases assigned to one of the four largest stereotyped M-CLL subsets, namely subsets #4, #16, #29 and #201, and investigated in detail their clinicobiological characteristics and disease outcomes. Results: We identified shared and subset-specific patterns of somatic hypermutation (SHM) among patients assigned to these subsets. The greatest similarity was observed between subsets #4 and #16, both including IgG-switched cases (IgG-CLL). In contrast, the least similarity was detected between subsets #16 and #201, the latter concerning IgM/D-expressing CLL. Significant differences between subsets also involved disease stage at diagnosis and the presence of specific genomic aberrations. IgG subsets #4 and #16 emerged as particularly indolent with a significantly (P < 0.05) longer time-to-first-treatment (TTFT; median TTFT: not yet reached) compared with the IgM/D subsets #29 and #201 (median TTFT: 11 and 12 years, respectively). Conclusions: Our findings support the notion that BcR IG stereotypy further refines prognostication in CLL, superseding the immunogenetic distinction based solely on SHM load. In addition, the observed distinct genetic aberration landscapes and clinical heterogeneity suggest that not all M-CLL cases are equal, prompting further research into the underlying biological background with the ultimate aim of tailored patient management.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- B-cell receptors
- gene mutational status
- antigen receptors
- CD38 expression
- genomic aberrations
- sequence-analysis
- I-antigen
- immunoglobulin
- antibodies
- dna
- LEUKEMIA
- IGHV4-34 Receptors
- Clinical Outcomes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Xochelli, Aliki
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Baliakas, Panagi ...
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Kavakiotis, Ioan ...
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Agathangelidis, ...
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Sutton, Lesley A ...
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Minga, Eva
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visa fler...
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Ntoufa, Stavroul ...
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Tausch, Eugen
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Yan, Xiao-Jie
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Shanafelt, Tait
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Plevova, Karla
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Boudjogra, Myria ...
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Rossi, Davide
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Davis, Zadie
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Navarro, Alba
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Sandberg, Yorick
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Vojdeman, Fie Ju ...
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Scarfo, Lydia
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Stavroyianni, Ni ...
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Sudarikov, Andre ...
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Veronese, Silvio
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Tzenou, Tatiana
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Karan-Djurasevic ...
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Catherwood, Mark
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Kienle, Dirk
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Chatzouli, Maria
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Facco, Monica
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Bahlo, Jasmin
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Pott, Christiane
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Pedersen, Lone B ...
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Mansouri, Larry
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Smedby, Karin E.
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Chu, Charles C.
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Giudicelli, Vero ...
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Lefranc, Marie-P ...
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Panagiotidis, Pa ...
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Juliusson, Gunna ...
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Anagnostopoulos, ...
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Vlahavas, Ioanni ...
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Antic, Darko
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Trentin, Livio
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Montillo, Marco
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Niemann, Carsten
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Doehner, Hartmut
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Langerak, Anton ...
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Pospisilova, Sar ...
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Hallek, Michael
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Campo, Elias
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Chiorazzi, Nicho ...
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Maglaveras, Niko ...
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Oscier, David
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Gaidano, Gianluc ...
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Jelinek, Diane F ...
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Stilgenbauer, St ...
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Chouvarda, Ioann ...
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Darzentas, Nikos
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Belessi, Chrysou ...
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Davi, Frederic
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Hadzidimitriou, ...
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Rosenquist, Rich ...
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Ghia, Paolo
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Stamatopoulos, K ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Genetik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Clinical Cancer ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet