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  • Gustafson, Elisabet K.Uppsala universitet,Barnkirurgi (author)

The Instant Blood-Mediated Inflammatory Reaction Characterized in Hepatocyte Transplantation

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-149561
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149561URI
  • https://doi.org/10.1097/TP.0b013e31820ae459DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background. Hepatocyte transplantation (HcTx) has proven to be a safe procedure, although the functional results have been unsatisfactory, probably due to insufficient engraftment or a loss of transplanted mass or function. In this study, we investigate whether hepatocytes in contact with blood induce an inflammatory reaction leading to, similar to what happens in clinical islet transplantation, an instant blood-mediated inflammatory reaction (IBMIR) resulting in an early loss of transplanted cells. Methods. By using an experimental model that mimics the portal vein blood flow, we could study different parameters reflecting the effects on the innate immunity elicited by hepatocytes in contact with ABO-matched human blood. Results. We report that all aspects of the IBMIR such as platelet and granulocyte consumption, coagulation, and complement activation were demonstrated. Addition of various specific inhibitors of coagulation allowed us to clearly delineate the various stages of the hepatocyte-triggered IBMIR and show that the reaction was triggered by tissue factor. Analysis of a case of clinical HcTx showed that hepatocyte-induced IBMIR also occurs in vivo. Both the inflammatory and the coagulation aspects were controlled by low-molecular-weight dextran sulfate. Conclusion. Isolated hepatocytes in contact with blood induce the IBMIR in vitro, and there are indications that these events are also relevant in vivo. According to these findings, HcTx would benefit from controlling a wider range of signals from the innate immune system.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Elgue, GracielaUppsala universitet,Klinisk immunologi (author)
  • Hughes, Robin D. (author)
  • Mitry, Ragai R. (author)
  • Sanchez, JavierUppsala universitet,Klinisk immunologi (author)
  • Haglund, UlfUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)ulfhagnd (author)
  • Meurling, StaffanUppsala universitet,Barnkirurgi(Swepub:uu)stafmeur (author)
  • Dhawan, Anil (author)
  • Korsgren, OlleUppsala universitet,Klinisk immunologi(Swepub:uu)ollekors (author)
  • Nilsson, BoUppsala universitet,Klinisk immunologi,Forskargrupp Bo Nilsson(Swepub:uu)bonils (author)
  • Uppsala universitetBarnkirurgi (creator_code:org_t)

Related titles

  • In:Transplantation91:6, s. 632-6380041-13371534-6080

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By the author/editor
Gustafson, Elisa ...
Elgue, Graciela
Hughes, Robin D.
Mitry, Ragai R.
Sanchez, Javier
Haglund, Ulf
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Meurling, Staffa ...
Dhawan, Anil
Korsgren, Olle
Nilsson, Bo
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Surgery
Articles in the publication
Transplantation
By the university
Uppsala University

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Elisabet_K_Gustafson
Gustafson, Elisabet K.
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