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  • Choi, Murim (author)

K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-149566
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149566URI
  • https://doi.org/10.1126/science.1198785DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of severe hypertension, feature constitutive hormone production and unrestrained cell proliferation; the mechanisms linking these events are unknown. We identify two recurrent somatic mutations in and near the selectivity filter of the potassium (K+) channel KCNJ5 that are present in 8 of 22 human APAs studied. Both produce increased sodium (Na+) conductance and cell depolarization, which in adrenal glomerulosa cells produces calcium (Ca2+) entry, the signal for aldosterone production and cell proliferation. Similarly, we identify an inherited KCNJ5 mutation that produces increased Na+ conductance in a Mendelian form of severe aldosteronism and massive bilateral adrenal hyperplasia. These findings explain pathogenesis in a subset of patients with severe hypertension and implicate loss of K+ channel selectivity in constitutive cell proliferation and hormone production.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Scholl, Ute I. (author)
  • Yue, Peng (author)
  • Björklund, PeymanUppsala universitet,Institutionen för kirurgiska vetenskaper(Swepub:uu)pebjo957 (author)
  • Zhao, Bixiao (author)
  • Nelson-Williams, Carol (author)
  • Ji, Weizhen (author)
  • Cho, Yoonsang (author)
  • Patel, Aniruddh (author)
  • Men, Clara J. (author)
  • Lolis, Elias (author)
  • Wisgerhof, Max V. (author)
  • Geller, David S. (author)
  • Mane, Shrikant (author)
  • Hellman, PerUppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi, Endocrine Surgery(Swepub:uu)perhellm (author)
  • Westin, GunnarUppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi, Endocrine Surgery(Swepub:uu)gunnwest (author)
  • Åkerström, GöranUppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi, Endocrine Surgery(Swepub:uu)goranas (author)
  • Wang, Wenhui (author)
  • Carling, Tobias (author)
  • Lifton, Richard P. (author)
  • Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)

Related titles

  • In:Science: American Association for the Advancement of Science (AAAS)331:6018, s. 768-7720036-80751095-9203

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