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Determinants of lun...
Determinants of lung function and airway hyperresponsiveness in asthmatic children
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Bisgaard, H (author)
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Pedersen, S (author)
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Anhøj, J (author)
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Agertoft, L (author)
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- Hedlin, G (author)
- Karolinska Institutet
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Gulsvik, A (author)
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- Bjermer, Leif (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Carlsen, K H (author)
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- Nordvall, L (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall
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Lundbäck, B (author)
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- Wennergren, Göran, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Werner, S (author)
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Bønnelykke, K (author)
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Weiss, S T (author)
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 101:7, s. 1477-1482
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Abstract
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- BackgroundAsthma patients exhibit an increased rate of loss of lung function. Determinants to such decline are largely unknown and the modifying effect of steroid therapy is disputed. This cross-sectional study aimed to elucidate factors contributing to such decline and the possible modifying effect of steroid treatment.MethodsWe analyzed determinants of lung function and airway hyperresponsiveness (AHR) in a Scandinavian study of 2390 subjects from 550 families. Families were selected for the presence of two or more asthmatic children as part of a genetic study, Scandinavian Asthma Genetic Study (SAGA).ResultsThe primary analysis studied the association between the lung function and delay of inhaled corticosteroids (ICS) after asthma diagnosis among asthmatic children and young adults with a history of regular ICS treatment (N=919). FEV1 percent predicted (FEV1% pred) was 0.25% lower per year of delay from diagnosis until treatment (p=0.039). This association was significantly greater in allergy skin prick test negative children. There was no significant influence of gender, age at asthma onset, or smoking.In the secondary analysis of the whole population of 2390 asthmatics and non-asthmatics, FEV1% pred was inversely related to having asthmatic siblings (−7.9%; p<0.0001), asthma diagnosis (−2.7%; p=0.0007), smoking (−3.5%; p=0.0027), and positive allergy skin prick test (−0.47% per test; p=0.012), while positively related to being of female gender (1.8%; p=0.0029). Risk of AHR was higher by having asthmatic siblings (OR 2.7; p<0.0001), being of female gender (OR 2.0; p<0.0001), and having asthma (OR 2.0; p<0.0001).ConclusionsThese data suggest that lung function is lower in asthmatics with delayed introduction of ICS therapy, smoking, and positive allergy skin prick test. Lung function is lower and AHR higher in female asthmatics and subjects with asthmatic siblings or established asthma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Adolescent
- Adult
- Age Factors
- Asthma/drug therapy/genetics/*physiopathology
- Bronchial Hyperreactivity/genetics/*physiopathology
- Child
- Cross-Sectional Studies
- Drug Administration Schedule
- Female
- Forced Expiratory Volume/drug effects
- Glucocorticoids/administration & dosage/therapeutic use
- Humans
- Male
- Smoking/physiopathology
- MEDICINE
- MEDICIN
- Adolescent
- Adult
- Age Factors
- Asthma/drug therapy/genetics/*physiopathology
- Bronchial Hyperreactivity/genetics/*physiopathology
- Child
- Cross-Sectional Studies
- Drug Administration Schedule
- Female
- Forced Expiratory Volume/drug effects
- Glucocorticoids/administration & dosage/therapeutic use
- Humans
- Male
- Smoking/physiopathology
- airway hyperresponsiveness
- steroid
- FEV1
- asthma
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bisgaard, H
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Pedersen, S
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Anhøj, J
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Agertoft, L
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Hedlin, G
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Gulsvik, A
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show more...
-
Bjermer, Leif
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Carlsen, K H
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Nordvall, L
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Lundbäck, B
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Wennergren, Göra ...
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Werner, S
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Bønnelykke, K
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Weiss, S T
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Respiratory Medi ...
- By the university
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Uppsala University
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University of Gothenburg
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Lund University
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Karolinska Institutet