AMNE:(MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases)
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- Pasupuleti, MukeshLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine (author)
Preservation of Antimicrobial Properties of Complement Peptide C3a, from Invertebrates to Humans
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- 2007
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-15071
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-15071URI
- https://doi.org/10.1074/jbc.M607848200DOI
- https://lup.lub.lu.se/record/164289URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The human anaphylatoxin peptide C3a, generated during complement activation, exerts antimicrobial effects. Phylogenetic analysis, sequence analyses, and structural modeling studies paired with antimicrobial assays of peptides from known C3a sequences showed that, in particular in vertebrate C3a, crucial structural determinants governing antimicrobial activity have been conserved during the evolution of C3a. Thus, regions of the ancient C3a from Carcinoscorpius rotundicauda as well as corresponding parts of human C3a exhibited helical structures upon binding to bacterial lipopolysaccharide permeabilized liposomes and were antimicrobial against Gram-negative and Gram-positive bacteria. Human C3a and C4a (but not C5a) were antimicrobial, in concert with the separate evolutionary development of the chemotactic C5a. Thus, the results demonstrate that, notwithstanding a significant sequence variation, functional and structural constraints imposed on C3a during evolution have preserved critical properties governing antimicrobial activity.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
- PHARMACY
- FARMACI
- MEDICINE
- MEDICIN
- NATURAL SCIENCES
- NATURVETENSKAP
Added entries (persons, corporate bodies, meetings, titles ...)
- Walse, B (author)
- Nordahl, EmmaLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infektionsmedicin,Institutionen för kliniska vetenskaper, Lund,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Infection Medicine (BMC),Department of Clinical Sciences, Lund(Swepub:lu)derm-ean (author)
- Malmsten, MartinUppsala University,Uppsala universitet,Institutionen för farmaci(Swepub:lu)ma1014ma (author)
- Schmidtchen, ArturLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)derm-asc (author)
- Mörgelin, MatthiasLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)medk-mmn (author)
- Dermatologi och venereologi, LundSektion III (creator_code:org_t)
Related titles
- In:Journal of Biological Chemistry282:4, s. 2520-25280021-92581083-351X
Internet link
- https://portal.research.lu.se/files/2722442/625815.pdfFULLTEXT
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17132627&dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1074/jbc.M607848200FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-15071
- https://doi.org/10.1074/jbc.M607848200
- https://lup.lub.lu.se/record/164289
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