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Associations of MAO...
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Wargelius, Hanna-LinnUppsala universitet,Farmakologi
(author)
Associations of MAOA-VNTR or 5HTT-LPR alleles with attention-deficit hyperactivity disorder symptoms are moderated by platelet monoamine oxidase B activity
- Article/chapterEnglish2012
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-151865
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151865URI
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https://doi.org/10.1097/YPG.0b013e328347c1abDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123784246URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The monoamine systems have been suggested to play a role in the biological basis of ADHD symptoms. Thus, polymorphisms in e.g. the monoamine oxidase A (MAOA) and the serotonin transporter (5HTT) genes have been associated with ADHD like phenotypes. Furthermore, platelet MAOB activity has frequently been linked to impulsiveness-related traits. In the present paper, we have studied ADHD symptoms with regard to the combination of platelet MAOB activity and MAOAVNTR or 5HTT-LPR genotype. The study group consisted of 156 adolescent twin pairs, i.e. 312 individuals, who were used in a previous study (Malmberg et al., 2008). ADHD symptoms were scored with a structured clinical interview of both the twin and a parent using Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version. Presence of a short 5HTT-LPR or short MAOA-VNTR allele, in combination with high levels of platelet MAOB enzyme activity was associated with higher scores of ADHD like problems (p<0.001; p<0.01, respectively). This reexamination of ADHD scores in a non-clinical sample suggests that effects of the MAOA-VNTR and 5HTT-LPR are moderated by platelet MAOB activity.
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Malmberg, KerstinKarolinska Institutet
(author)
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Larsson, Jan-OlovKarolinska Institutet
(author)
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Oreland, LarsUppsala universitet,Farmakologi(Swepub:uu)larsore
(author)
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Uppsala universitetFarmakologi
(creator_code:org_t)
Related titles
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In:Psychiatric Genetics22:1, s. 42-450955-88291473-5873
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