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A genome-wide assoc...
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
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Peden, John F. (author)
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Hopewell, Jemma C. (author)
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Saleheen, Danish (author)
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show more...
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Chambers, John C. (author)
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Hager, Jorg (author)
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Soranzo, Nicole (author)
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Collins, Rory (author)
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Danesh, John (author)
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Elliott, Paul (author)
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- Farrall, Martin (author)
- Karolinska Institutet
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Stirrups, Kathy (author)
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Zhang, Weihua (author)
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- Hamsten, Anders (author)
- Karolinska Institutet
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Parish, Sarah (author)
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- Lathrop, Mark (author)
- Karolinska Institutet
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Watkins, Hugh (author)
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Clarke, Robert (author)
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Deloukas, Panos (author)
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Kooner, Jaspal S. (author)
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Goel, Anuj (author)
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Ongen, Halit (author)
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- Strawbridge, Rona J. (author)
- Karolinska Institutet
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Heath, Simon (author)
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- Mälarstig, Anders (author)
- Karolinska Institutet
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Helgadottir, Anna (author)
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- Öhrvik, John (author)
- Karolinska Institutet
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Murtaza, Muhammed (author)
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Potter, Simon (author)
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Hunt, Sarah E. (author)
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Delepine, Marc (author)
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Jalilzadeh, Shapour (author)
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- Axelsson, Tomas (author)
- Uppsala universitet,Molekylär medicin
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin
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Gwilliam, Rhian (author)
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Bumpstead, Suzannah (author)
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Gray, Emma (author)
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Edkins, Sarah (author)
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- Folkersen, Lasse (author)
- Karolinska Institutet
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Kyriakou, Theodosios (author)
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- Franco-Cereceda, Anders (author)
- Karolinska Institutet
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- Gabrielsen, Anders (author)
- Karolinska Institutet
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Seedorf, Udo (author)
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- Eriksson, Per (author)
- Karolinska Institutet
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Offer, Alison (author)
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Bowman, Louise (author)
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Sleight, Peter (author)
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Armitage, Jane (author)
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Peto, Richard (author)
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Abecasis, Goncalo (author)
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Ahmed, Nabeel (author)
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Caulfield, Mark (author)
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Donnelly, Peter (author)
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Froguel, Philippe (author)
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- Kooner, Angad S. (author)
- Karolinska Institutet
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McCarthy, Mark I. (author)
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Samani, Nilesh J. (author)
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Scott, James (author)
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Sehmi, Joban (author)
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Silveira, Angela (author)
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Hellenius, Mai-Lis (author)
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van't Hooft, Ferdinand M. (author)
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Olsson, Gunnar (author)
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Rust, Stephan (author)
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Assmann, Gerd (author)
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Barlera, Simona (author)
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Tognoni, Gianni (author)
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Franzosi, Maria Grazia (author)
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Linksted, Pamela (author)
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Green, Fiona R. (author)
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Rasheed, Asif (author)
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Zaidi, Moazzam (author)
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Shah, Nabi (author)
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Samuel, Maria (author)
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Mallick, Nadeem H. (author)
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Azhar, Muhammad (author)
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Zaman, Khan S. (author)
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Samad, Abdus (author)
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Ishaq, Mohammad (author)
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Gardezi, Ali R. (author)
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Memon, Fazal-ur-Rehman (author)
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Frossard, Philippe M. (author)
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Spector, Tim (author)
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Peltonen, Leena (author)
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Nieminen, Markku S. (author)
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Sinisalo, Juha (author)
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Salomaa, Veikko (author)
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Ripatti, Samuli (author)
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Bennett, Derrick (author)
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- Leander, Karin (author)
- Karolinska Institutet
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- Gigante, Bruna (author)
- Karolinska Institutet
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- de Faire, Ulf (author)
- Karolinska Institutet
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Pietri, Silvia (author)
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Gori, Francesca (author)
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Marchioli, Roberto (author)
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Sivapalaratnam, Suthesh (author)
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Kastelein, John J. P. (author)
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Trip, Mieke D. (author)
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Theodoraki, Eirini V. (author)
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Dedoussis, George V. (author)
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Engert, Jamie C. (author)
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Yusuf, Salim (author)
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Anand, Sonia S. (author)
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(creator_code:org_t)
- 2011-03-06
- 2011
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:4, s. 339-344
- Related links:
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https://www.openacce...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with similar to 575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 x 10(-8) in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Peden, John F.
-
Hopewell, Jemma ...
-
Saleheen, Danish
-
Chambers, John C ...
-
Hager, Jorg
-
Soranzo, Nicole
-
show more...
-
Collins, Rory
-
Danesh, John
-
Elliott, Paul
-
Farrall, Martin
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Stirrups, Kathy
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Zhang, Weihua
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Hamsten, Anders
-
Parish, Sarah
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Lathrop, Mark
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Watkins, Hugh
-
Clarke, Robert
-
Deloukas, Panos
-
Kooner, Jaspal S ...
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Goel, Anuj
-
Ongen, Halit
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Strawbridge, Ron ...
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Heath, Simon
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Mälarstig, Ander ...
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Helgadottir, Ann ...
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Öhrvik, John
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Murtaza, Muhamme ...
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Potter, Simon
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Hunt, Sarah E.
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Delepine, Marc
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Jalilzadeh, Shap ...
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Axelsson, Tomas
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Syvänen, Ann-Chr ...
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Gwilliam, Rhian
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Bumpstead, Suzan ...
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Gray, Emma
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Edkins, Sarah
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Folkersen, Lasse
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Kyriakou, Theodo ...
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Franco-Cereceda, ...
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Gabrielsen, Ande ...
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Seedorf, Udo
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Eriksson, Per
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Offer, Alison
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Bowman, Louise
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Sleight, Peter
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Armitage, Jane
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Peto, Richard
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Abecasis, Goncal ...
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Ahmed, Nabeel
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Caulfield, Mark
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Donnelly, Peter
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Froguel, Philipp ...
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Kooner, Angad S.
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McCarthy, Mark I ...
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Samani, Nilesh J ...
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Scott, James
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Sehmi, Joban
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Silveira, Angela
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Hellenius, Mai-L ...
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van't Hooft, Fer ...
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Olsson, Gunnar
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Rust, Stephan
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Assmann, Gerd
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Barlera, Simona
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Tognoni, Gianni
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Franzosi, Maria ...
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Linksted, Pamela
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Green, Fiona R.
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Rasheed, Asif
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Zaidi, Moazzam
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Shah, Nabi
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Samuel, Maria
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Mallick, Nadeem ...
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Azhar, Muhammad
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Zaman, Khan S.
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Samad, Abdus
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Ishaq, Mohammad
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Gardezi, Ali R.
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Memon, Fazal-ur- ...
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Frossard, Philip ...
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Spector, Tim
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Peltonen, Leena
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Nieminen, Markku ...
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Sinisalo, Juha
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Salomaa, Veikko
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Ripatti, Samuli
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Bennett, Derrick
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Leander, Karin
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Gigante, Bruna
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de Faire, Ulf
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Pietri, Silvia
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Gori, Francesca
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Marchioli, Rober ...
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Sivapalaratnam, ...
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Kastelein, John ...
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Trip, Mieke D.
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Theodoraki, Eiri ...
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Dedoussis, Georg ...
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Engert, Jamie C.
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Yusuf, Salim
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Anand, Sonia S.
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- Articles in the publication
-
Nature Genetics
- By the university
-
Uppsala University
-
Karolinska Institutet