A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

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Peden, John F. (author)

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

Article/chapterEnglish2011

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2011-03-06
Springer Science and Business Media LLC,2011
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LIBRIS-ID:oai:DiVA.org:uu-151963
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151963URI
https://doi.org/10.1038/ng.782DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:122295668URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with similar to 575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 x 10(-8) in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.

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MEDICINE
MEDICIN

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Hopewell, Jemma C. (author)
Saleheen, Danish (author)
Chambers, John C. (author)
Hager, Jorg (author)
Soranzo, Nicole (author)
Collins, Rory (author)
Danesh, John (author)
Elliott, Paul (author)
Farrall, MartinKarolinska Institutet (author)
Stirrups, Kathy (author)
Zhang, Weihua (author)
Hamsten, AndersKarolinska Institutet (author)
Parish, Sarah (author)
Lathrop, MarkKarolinska Institutet (author)
Watkins, Hugh (author)
Clarke, Robert (author)
Deloukas, Panos (author)
Kooner, Jaspal S. (author)
Goel, Anuj (author)
Ongen, Halit (author)
Strawbridge, Rona J.Karolinska Institutet (author)
Heath, Simon (author)
Mälarstig, AndersKarolinska Institutet (author)
Helgadottir, Anna (author)
Öhrvik, JohnKarolinska Institutet (author)
Murtaza, Muhammed (author)
Potter, Simon (author)
Hunt, Sarah E. (author)
Delepine, Marc (author)
Jalilzadeh, Shapour (author)
Axelsson, TomasUppsala universitet,Molekylär medicin(Swepub:uu)toaxe957 (author)
Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin(Swepub:uu)anncsyva (author)
Gwilliam, Rhian (author)
Bumpstead, Suzannah (author)
Gray, Emma (author)
Edkins, Sarah (author)
Folkersen, LasseKarolinska Institutet (author)
Kyriakou, Theodosios (author)
Franco-Cereceda, AndersKarolinska Institutet (author)
Gabrielsen, AndersKarolinska Institutet (author)
Seedorf, Udo (author)
Eriksson, PerKarolinska Institutet (author)
Offer, Alison (author)
Bowman, Louise (author)
Sleight, Peter (author)
Armitage, Jane (author)
Peto, Richard (author)
Abecasis, Goncalo (author)
Ahmed, Nabeel (author)
Caulfield, Mark (author)
Donnelly, Peter (author)
Froguel, Philippe (author)
Kooner, Angad S.Karolinska Institutet (author)
McCarthy, Mark I. (author)
Samani, Nilesh J. (author)
Scott, James (author)
Sehmi, Joban (author)
Silveira, Angela (author)
Hellenius, Mai-Lis (author)
van't Hooft, Ferdinand M. (author)
Olsson, Gunnar (author)
Rust, Stephan (author)
Assmann, Gerd (author)
Barlera, Simona (author)
Tognoni, Gianni (author)
Franzosi, Maria Grazia (author)
Linksted, Pamela (author)
Green, Fiona R. (author)
Rasheed, Asif (author)
Zaidi, Moazzam (author)
Shah, Nabi (author)
Samuel, Maria (author)
Mallick, Nadeem H. (author)
Azhar, Muhammad (author)
Zaman, Khan S. (author)
Samad, Abdus (author)
Ishaq, Mohammad (author)
Gardezi, Ali R. (author)
Memon, Fazal-ur-Rehman (author)
Frossard, Philippe M. (author)
Spector, Tim (author)
Peltonen, Leena (author)
Nieminen, Markku S. (author)
Sinisalo, Juha (author)
Salomaa, Veikko (author)
Ripatti, Samuli (author)
Bennett, Derrick (author)
Leander, KarinKarolinska Institutet (author)
Gigante, BrunaKarolinska Institutet (author)
de Faire, UlfKarolinska Institutet (author)
Pietri, Silvia (author)
Gori, Francesca (author)
Marchioli, Roberto (author)
Sivapalaratnam, Suthesh (author)
Kastelein, John J. P. (author)
Trip, Mieke D. (author)
Theodoraki, Eirini V. (author)
Dedoussis, George V. (author)
Engert, Jamie C. (author)
Yusuf, Salim (author)
Anand, Sonia S. (author)
Karolinska InstitutetMolekylär medicin (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC43:4, s. 339-3441061-40361546-1718

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By the author/editor: Peden, John F.; Hopewell, Jemma ...; Saleheen, Danish; Chambers, John C ...; Hager, Jorg; Soranzo, Nicole; show more...; Collins, Rory; Danesh, John; Elliott, Paul; Farrall, Martin; Stirrups, Kathy; Zhang, Weihua; Hamsten, Anders; Parish, Sarah; Lathrop, Mark; Watkins, Hugh; Clarke, Robert; Deloukas, Panos; Kooner, Jaspal S ...; Goel, Anuj; Ongen, Halit; Strawbridge, Ron ...; Heath, Simon; Mälarstig, Ander ...; Helgadottir, Ann ...; Öhrvik, John; Murtaza, Muhamme ...; Potter, Simon; Hunt, Sarah E.; Delepine, Marc; Jalilzadeh, Shap ...; Axelsson, Tomas; Syvänen, Ann-Chr ...; Gwilliam, Rhian; Bumpstead, Suzan ...; Gray, Emma; Edkins, Sarah; Folkersen, Lasse; Kyriakou, Theodo ...; Franco-Cereceda, ...; Gabrielsen, Ande ...; Seedorf, Udo; Eriksson, Per; Offer, Alison; Bowman, Louise; Sleight, Peter; Armitage, Jane; Peto, Richard; Abecasis, Goncal ...; Ahmed, Nabeel; Caulfield, Mark; Donnelly, Peter; Froguel, Philipp ...; Kooner, Angad S.; McCarthy, Mark I ...; Samani, Nilesh J ...; Scott, James; Sehmi, Joban; Silveira, Angela; Hellenius, Mai-L ...; van't Hooft, Fer ...; Olsson, Gunnar; Rust, Stephan; Assmann, Gerd; Barlera, Simona; Tognoni, Gianni; Franzosi, Maria ...; Linksted, Pamela; Green, Fiona R.; Rasheed, Asif; Zaidi, Moazzam; Shah, Nabi; Samuel, Maria; Mallick, Nadeem ...; Azhar, Muhammad; Zaman, Khan S.; Samad, Abdus; Ishaq, Mohammad; Gardezi, Ali R.; Memon, Fazal-ur- ...; Frossard, Philip ...; Spector, Tim; Peltonen, Leena; Nieminen, Markku ...; Sinisalo, Juha; Salomaa, Veikko; Ripatti, Samuli; Bennett, Derrick; Leander, Karin; Gigante, Bruna; de Faire, Ulf; Pietri, Silvia; Gori, Francesca; Marchioli, Rober ...; Sivapalaratnam, ...; Kastelein, John ...; Trip, Mieke D.; Theodoraki, Eiri ...; Dedoussis, Georg ...; Engert, Jamie C.; Yusuf, Salim; Anand, Sonia S.; show less...

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