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Increase in hypotha...
Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids : PET study with [C-11]vorozole
- Article/chapterEnglish2011
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-152829
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-152829URI
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https://doi.org/10.1097/WNR.0b013e3283460282DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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In an earlier study in rodents, we showed that the aromatase that converts androgens to estrogens in the preoptic area and bed nucleus of stria terminalis was significantly increased in concentration after exposure to anabolic-androgenic steroids. To confirm whether this occurs in primates, we conducted a positron emission tomographic study using macaque monkeys. Male rhesus monkeys were treated with nandrolone decanoate for 3 weeks. To measure aromatase concentrations, we performed positron emission tomographic imaging using a C-11-labeled specific aromatase inhibitor, [C-11] vorozole. After treatment with nandrolone, significant increase in [C-11] vorozole binding was observed in the hypothalamus but not other areas including the amygdala, which is also aromatase enriched. These findings in monkeys are consistent with those we obtained earlier in rats. These findings strongly suggest that aromatase in the hypothalamus may play a crucial role in the emotional instability of anabolic-androgenic steroids abusers. NeuroReport 22:326-330 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Subject headings and genre
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anabolic-androgenic steroids
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aromatase
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hypothalamus
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monkey
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positron emission tomography
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NATURAL SCIENCES
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NATURVETENSKAP
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Onoe, Kayo
(author)
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Doi, Hisashi
(author)
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Nagata, Hiroko
(author)
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Yamagishi, Gen
(author)
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Hosoya, Takamitsu
(author)
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Tamura, Yasuhisa
(author)
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Wada, Yasuhiro
(author)
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Yamanaka, Hajime
(author)
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Yokoyama, Chihiro
(author)
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Mizuma, Hiroshi
(author)
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Takashima, Tadayuki
(author)
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Bergström, MatsUppsala universitet,Enheten för nuklearmedicin och PET
(author)
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Onoe, Hirotaka
(author)
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Långström, BengtUppsala universitet,Institutionen för biokemi och organisk kemi(Swepub:uu)benglang
(author)
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Watanabe, Yasuyoshi
(author)
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Uppsala universitetEnheten för nuklearmedicin och PET
(creator_code:org_t)
Related titles
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In:NeuroReport22:7, s. 326-3300959-49651473-558X
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Takahashi, Kayo
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Onoe, Kayo
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Doi, Hisashi
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Nagata, Hiroko
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Yamagishi, Gen
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Hosoya, Takamits ...
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show more...
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Tamura, Yasuhisa
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Wada, Yasuhiro
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Yamanaka, Hajime
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Yokoyama, Chihir ...
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Mizuma, Hiroshi
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Takashima, Taday ...
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Bergström, Mats
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Onoe, Hirotaka
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Långström, Bengt
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Watanabe, Yasuyo ...
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NeuroReport
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Uppsala University