Cerebrolysin Attenuates Heat Shock Protein (HSP 72 KD) Expression in the Rat Spinal Cord Following Morphine Dependence and Withdrawal: Possible New Therapy for Pain Management

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Sharma, Hari S.Uppsala universitet,Anestesiologi och intensivvård (författare)

Cerebrolysin Attenuates Heat Shock Protein (HSP 72 KD) Expression in the Rat Spinal Cord Following Morphine Dependence and Withdrawal : Possible New Therapy for Pain Management

Artikel/kapitelEngelska2011

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2011
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LIBRIS-ID:oai:DiVA.org:uu-152857
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-152857URI

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Språk:engelska
Sammanfattning på:engelska

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The possibility that pain perception and processing in the CNS results in cellular stress and may influence heat shock protein (HSP) expression was examined in a rat model of morphine dependence and withdrawal. Since activation of pain pathways result in exhaustion of growth factors, we examined the influence of cerebrolysin, a mixture of potent growth factors (BDNF, GDNF, NGF, CNTF etc,) on morphine induced HSP expression. Rats were administered morphine (10 mg/kg, s.c. /day) for 12 days and the spontaneous withdrawal symptoms were developed by cessation of the drug administration on day 13(th) that were prominent on day 14(th) and continued up to day 15(th) (24 to 72 h periods). In a separate group of rats, cerebrolysin was infused intravenously (5 ml/kg) once daily from day one until day 15(th). In these animals, morphine dependence and withdrawal along with HSP immunoreactivity was examined using standard protocol. In untreated group mild HSP immunoreaction was observed during morphine tolerance, whereas massive upregulation of HSP was seen in CNS during withdrawal phase that correlated well with the withdrawal symptoms and neuronal damage. Pretreatment with cerebrolysin did not affect morphine tolerance but reduced the HSP expression during this phase. Furthermore, cerebrolysin reduced the withdrawal symptoms on day 14(th) to 15(th). Taken together these observations suggest that cellular stress plays an important role in morphine induced pain pathology and exogenous supplement of growth factors, i.e. cerebrolysin attenuates HSP expression in the CNS and induce neuroprotection. This indicates a new therapeutic role of cerebrolysin in the pathophysiology of drugs of abuse, not reported earlier.

Ämnesord och genrebeteckningar

Morphine
heat shock proteins (HSP 72 kD)
morphine tolerance
withdrawal symptoms
stress reaction
cerebrolysin
growth factors
pain perception
analgesia
MEDICINE
MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

Ali, Syed F. (författare)
Patnaik, Ranjana (författare)
Zimmermann-Meinzingen, Sibilla (författare)
Sharma, ArunaUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)arush975 (författare)
Muresanu, Dafin F. (författare)
Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)

Sammanhörande titlar

Ingår i:Current Neuropharmacology9:1, s. 223-2351570-159X1875-6190

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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-152857

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Current Neuropharmacology (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Sharma, Hari S.; Ali, Syed F.; Patnaik, Ranjana; Zimmermann-Meinz ...; Sharma, Aruna; Muresanu, Dafin ...

Artiklar i publikationen: Current Neuropha ...

Av lärosätet: Uppsala universitet

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