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Diagnosis of a pati...
Diagnosis of a patient with oncogenic osteomalacia using a phosphate uptake bioassay of serum and magnetic resonance imaging
- Article/chapterEnglish2001
Publisher, publication year, extent ...
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Oxford University Press (OUP),2001
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-153010
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-153010URI
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https://doi.org/10.1530/eje.0.1450469DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A previously healthy man with no family history of fractures presented with muscle pain, back pain and height loss. Investigations revealed hypophosphataemia, phosphaturia, undetectable serum 1,25-dihydroxyvitamin D and severe osteomalacia on bone biopsy, suggestive of a diagnosis of oncogenic osteomalacia. Thorough physical examination did not locate a tumour. Support for the diagnosis was obtained by detection of phosphate uptake inhibitory activity in a blinded sample of the patient's serum using a renal cell bioassay. On the basis of detection of this bioactivity, a total body magnetic resonance (MR) examination was performed. A small tumour was located in the right leg. Removal of the tumour resulted in the rapid reversal of symptoms and the abnormal biochemistry typical of oncogenic osteomalacia. Inhibitory activity was also demonstrated using the bioassay in serum from two other patients with confirmed or presumptive oncogenic osteomalacia, but not in serum from two patients with hypophosphataemia of other origin. This is the first case to be reported in which the diagnosis of oncogenic osteomalacia was assisted by demonstration of inhibitory activity of the patient's serum in a renal cell phosphate bioassay that provided an impetus for total body MR imaging.
Added entries (persons, corporate bodies, meetings, titles ...)
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Mason, R S
(author)
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Robinson, B G
(author)
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Hogan, J J
(author)
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Martin, E A
(author)
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Ahlström, HåkanUppsala universitet,Enheten för radiologi
(author)
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Åström, GunnarUppsala universitet,Enheten för radiologi
(author)
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Larsson, T
(author)
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Jonsson, K
(author)
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Wibell, L
(author)
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Ljunggren, O
(author)
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Uppsala universitetEnheten för radiologi
(creator_code:org_t)
Related titles
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In:European Journal of Endocrinology: Oxford University Press (OUP)145:4, s. 469-4760804-46431479-683X
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Nelson, A E
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Mason, R S
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Robinson, B G
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Hogan, J J
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Martin, E A
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Ahlström, Håkan
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Åström, Gunnar
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Larsson, T
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Jonsson, K
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Wibell, L
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Ljunggren, O
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European Journal ...
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Uppsala University