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- Portala, Kamilla,1961-Uppsala universitet,Institutionen för neurovetenskap (författare)
Psychopathology in Wilson's Disease
- BokEngelska2001
Förlag, utgivningsår, omfång ...
- Uppsala :Acta Universitatis Upsaliensis,2001
- 61 s.
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-1535
- ISBN:9155451675
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1535URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Serie
- Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,0282-7476 ;1101
Anmärkningar
- Wilson's disease (WD), bepatolenticular degeneration, is an autosomal recessive disorder caused by mutations in the ATP7B gene, and is characterised by abnormal metabolism and deposition of copper in the liver, brain and other organs. The main aim of this thesis was to investigate the occurrence of psychopathology, as well as personality traits and neuropsychological function in Swedish patients with treated WD. The research subjects were 29 patients with confirmed WD, investigated at the Department of Internal Medicine at Uppsala University Hospital between 1996 and 2000. The treated WD patients showed prominent psychopathology as determined by the Comprehensive Psychopathological Rating Scale. The spectrum of psychopathological symptoms is not typical of classic psychiatric syndromes, and includes symptoms from Anxiety, Depression and Obsessive-Compulsive disorders as well as Negative Symptoms. In self-assessment, the WD patients tended to underestimate the presence of psychopathological symptoms. The treated WD patients differed in their sleep pattern from the control group, as measured with the Uppsala Sleep Inventory. The spectrum of self-reported symptoms suggests an altered REM sleep function. The treated WD patients had significant deviations in personality traits, especially in aggressivity-hostility related scales and Psychic anxiety, compared to healthy controls, as measured with the Karolinska Scales of Personality. The deviations were not related to age, age at onset or duration of WD. The treated WD patients displayed a specific profile of moderate neuropsychological impairment, as determined by the Automated Psychological Test battery. Finally, an attempt was made to search for, possible genotype-phenotype relationships in some ATP7B mutations.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- Neurosciences
- Wilson´s disease
- psychopathology. personality traits
- neuropsychological impairment
- sleep
- CPRS
- KSP
- Neurovetenskap
- Neurology
- Neurologi
- Psychiatry
- psykiatri
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Rembeck, Birgitta,DocentInst. för Neurovetenskap, Sektionen för Psykiatri, Göteborgs universitet, Göteborg (opponent)
- Uppsala universitetInstitutionen för neurovetenskap (creator_code:org_t)
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