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Gene expression ana...
Gene expression analysis for the prediction of recurrence in patients with primary Ta urothelial cell carcinoma
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Schultz, Iman J (författare)
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- Wester, Kenneth (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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Straatman, Huub (författare)
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Kiemeney, Lambertus A (författare)
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Babjuk, Marko (författare)
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Mares, Jaroslav (författare)
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Willems, Johannes L (författare)
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Swinkels, Dorine W (författare)
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Witjes, J Alfred (författare)
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- Malmström, Per-Uno (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Urologi
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de Kok, Jacques B (författare)
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- Engelska.
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Ingår i: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 51:2, s. 416-423
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives The individual recurrence-free period after primary surgery of patients with Ta urothelial cell carcinoma (UCC) cannot be predicted accurately. This study aims at discriminating between patients with primary Ta UCC and long or short recurrence-free periods. Methods We investigated mRNA expression of 23 genes in 44 primary Ta tumours (23 and 21 tumours were from patients with long [≥4 yr] or short [≤2 yr] recurrence-free periods, respectively), using real-time quantitative polymerase chain reaction. The genes were selected from previously published studies and showed a relationship with tumour recurrence in patients with UCC. Results Differential mRNA expression between the two patient groups indicated statistical significance only for the gene survivin (p = 0.0011). Its recurrence predictive value could not be increased by a combination with any of the other genes. Comparison of the receiver operating characteristic curves for survivin expression between patients with long or short recurrence-free intervals revealed an area under the curve of 0.79 (95%CI, 0.65–0.92). Using the median expression (0.84) as cut-off level, survivin identified 71.4% (95%CI, 47.8–88.7) and 69.6% (95%CI, 47.1–86.8) of the patients with long or short recurrence-free periods, respectively. Conclusions Our study identifies survivin as the most promising candidate to distinguish between patients with primary Ta UCC and long or short recurrence-free intervals. Therefore, survivin mRNA expression analysis might help the urologist to individualise patient treatment and prevent unnecessary cystoscopies in a subgroup of these patients.
Nyckelord
- Adult
- Aged
- Aged; 80 and over
- Carcinoma; Transitional Cell/*genetics/*surgery
- Female
- Gene Expression Profiling
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence; Local/*genetics
- Predictive Value of Tests
- RNA; Neoplasm/biosynthesis
- Urinary Bladder Neoplasms/*genetics/*surgery
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Schultz, Iman J
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Wester, Kenneth
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Straatman, Huub
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Kiemeney, Lamber ...
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Babjuk, Marko
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Mares, Jaroslav
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visa fler...
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Willems, Johanne ...
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Swinkels, Dorine ...
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Witjes, J Alfred
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Malmström, Per-U ...
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de Kok, Jacques ...
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visa färre...
- Artiklar i publikationen
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European Urology
- Av lärosätet
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Uppsala universitet