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TAR-DNA binding pro...
TAR-DNA binding protein-43 and alterations in the hippocampus
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Rauramaa, Tuomas (author)
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Pikkarainen, Maria (author)
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- Englund, Elisabet (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Ince, Paul G. (author)
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Jellinger, Kurt (author)
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Paetau, Anders (author)
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- Alafuzoff, Irina (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Alafuzoff
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(creator_code:org_t)
- 2011-01-06
- 2011
- English.
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In: Journal of neural transmission. - : Springer Science and Business Media LLC. - 0300-9564 .- 1435-1463. ; 118:5, s. 683-689
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- TAR-DNA binding protein-43
- Hyperphosphorylated-tau
- p62
- Immunohistochemistry
- Post-mortem
- Hippocampal alterations
- MEDICINE
- MEDICIN
- TAR-DNA binding protein-43
- Hyperphosphorylated-tau
- p62
- Immunohistochemistry
- Post-mortem
- Hippocampal alterations
Publication and Content Type
- ref (subject category)
- art (subject category)
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