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TAR-DNA binding pro...
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Rauramaa, Tuomas
(författare)
TAR-DNA binding protein-43 and alterations in the hippocampus
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2011-01-06
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Springer Science and Business Media LLC,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-154292
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-154292URI
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https://doi.org/10.1007/s00702-010-0574-5DOI
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https://lup.lub.lu.se/record/1986799URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pikkarainen, Maria
(författare)
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Englund, ElisabetLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-een
(författare)
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Ince, Paul G.
(författare)
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Jellinger, Kurt
(författare)
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Paetau, Anders
(författare)
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Alafuzoff, IrinaUppsala universitet,Institutionen för immunologi, genetik och patologi,Alafuzoff(Swepub:uu)irial548
(författare)
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TumörmikromiljöSektion I
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of neural transmission: Springer Science and Business Media LLC118:5, s. 683-6890300-95641435-1463
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