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PTAA and B10 :
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Kieninger, Barbara
(författare)
PTAA and B10 : new approaches to amyloid detection in tissue-evaluation of amyloid detection in tissue with a conjugated polyelectrolyte and a fibril-specific antibody fragment
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2011-03-14
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Informa UK Limited,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-154351
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-154351URI
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https://doi.org/10.3109/13506129.2011.560623DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Methods: aEuro integral We compared the amyloid detection of PTAA and B10 to Congo red in 106 amyloid-containing tissue biopsies of diverse anatomical and precursor origin by evaluating the accordance in four grades (grade 0: no staining, grade 1: staining of < 33%% of the amyloid deposits, grade 2: 33--66%% and grade 3: aEuroS > 66%%). Results: aEuro integral PTAA showed grade 2--3 staining in 57 (54%%) cases, while B10 presented this accordance in only 25 (24%%) tissue biopsies. Grade 1 staining was found in 11 (10%%) samples with PTAA and in 62 (58%%) cases with B10. No staining at all (grade 0) occurred in 38 (36%%) biopsies when using PTAA and in 19 (18%%) cases when using B10. Conclusion: aEuro integral Although conformation-sensitive detection seemed promising, PTAA and B10 stain only a fraction of the examined amyloid samples when using routine surgical pathology settings. This study emphasises the necessity of having optimised pre-analytical protocols for recovery, storage and handling of samples if these novel amyloid ligands are to be used in routine diagnosis of amyloid.
Ämnesord och genrebeteckningar
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amyloid
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PTAA
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camelid antibody
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gioeva, Zarina
(författare)
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Krueger, Sandra
(författare)
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Westermark, Gunilla T.Uppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)gunwe105
(författare)
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Friedrich, Ralf P.
(författare)
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Faendrich, Marcus
(författare)
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Roecken, Christoph
(författare)
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Uppsala universitetInstitutionen för medicinsk cellbiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Amyloid: Informa UK Limited18:2, s. 47-521350-61291744-2818
Internetlänk
Hitta via bibliotek
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Amyloid
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