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Are blood pressure ...
Are blood pressure and diabetes additive or synergistic risk factors? : outcome in 8494 subjects randomly recruited from 10 populations
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Sehestedt, Thomas (författare)
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Hansen, Tine W. (författare)
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Li, Yan (författare)
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visa fler...
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Richart, Tom (författare)
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Boggia, Jose (författare)
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Kikuya, Masahiro (författare)
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Thijs, Lutgarde (författare)
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Stolarz-Skrzypek, Katarzyna (författare)
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Casiglia, Edoardo (författare)
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Tikhonoff, Valerie (författare)
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Malyutina, Sofia (författare)
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Nikitin, Yuri (författare)
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- Björklund-Bodegård, Kristina (författare)
- Uppsala universitet,Geriatrik
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Kuznetsova, Tatiana (författare)
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Ohkubo, Takayoshi (författare)
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Torp-Pedersen, Christian (författare)
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Jeppesen, Jorgen (författare)
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Ibsen, Hans (författare)
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Imai, Yutaka (författare)
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Wang, Jiguang (författare)
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Sandoya, Edgardo (författare)
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Kawecka-Jaszcz, Kalina (författare)
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Staessen, Jan A. (författare)
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(creator_code:org_t)
- 2011-02-10
- 2011
- Engelska.
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Ingår i: Hypertension Research. - : Springer Science and Business Media LLC. - 0916-9636 .- 1348-4214. ; 34:6, s. 714-721
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- It remains unknown whether diabetes and high blood pressure (BP) are simply additive risk factors for cardiovascular outcome or whether they act synergistically and potentiate one another. We performed 24-h ambulatory BP monitoring in 8494 subjects (mean age, 54.6 years; 47.0% women; 6.9% diabetic patients) enrolled in prospective population studies in 10 countries. In multivariable-adjusted Cox regression, we assessed the additive as opposed to the synergistic effects of BP and diabetes in relation to a composite cardiovascular endpoint by testing the significance of appropriate interaction terms. During 10.6 years (median follow-up), 1066 participants had a cardiovascular complication. Diabetes mellitus as well as the 24-h ambulatory BP were independent and powerful predictors of the composite cardiovascular endpoint. However, there was no synergistic interaction between diabetes and 24-h, daytime, or nighttime, systolic or diastolic ambulatory BP (P for interaction, 0.07 <= P <= 0.97). The only exception was a borderline synergistic effect between diabetes and daytime diastolic BP in relation to the composite cardiovascular endpoint (P=0.04). In diabetic patients, with normotension as the reference group, the adjusted hazard ratios for the cardiovascular endpoint were 1.35 (95% confidence interval (CI), 0.87-2.11) for white-coat hypertension, 1.78 (95% CI, 1.22-2.60) for masked hypertension and 2.44 (95% CI, 1.92-3.11) for sustained hypertension. The hazard ratios for non-diabetic subjects were not different from those of diabetic patients (P-values for interaction, 0.09 <= P <= 0.72). In conclusion, in a large international population-based database, both diabetes mellitus and BP contributed equally to the risk of cardiovascular complications without evidence for a synergistic effect. Hypertension Research (2011) 34, 714-721; doi:10.1038/hr.2011.6; published online 10 February 2011
Nyckelord
- ambulatory blood pressure
- cardiovascular risk factors
- diabetes mellitus
- epidemiology
- population science
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Sehestedt, Thoma ...
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Hansen, Tine W.
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Li, Yan
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Richart, Tom
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Boggia, Jose
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Kikuya, Masahiro
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visa fler...
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Thijs, Lutgarde
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Stolarz-Skrzypek ...
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Casiglia, Edoard ...
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Tikhonoff, Valer ...
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Malyutina, Sofia
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Nikitin, Yuri
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Björklund-Bodegå ...
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Kuznetsova, Tati ...
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Ohkubo, Takayosh ...
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Lind, Lars
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Torp-Pedersen, C ...
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Jeppesen, Jorgen
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Ibsen, Hans
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Imai, Yutaka
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Wang, Jiguang
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Sandoya, Edgardo
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Kawecka-Jaszcz, ...
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Staessen, Jan A.
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visa färre...
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Hypertension Res ...
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Uppsala universitet