SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Medema Jan Paul)
 

Search: WFRF:(Medema Jan Paul) > Disruption of hepar...

  • Reijmers, Rogier M. (author)

Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • American Society of Hematology,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-155601
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-155601URI
  • https://doi.org/10.1182/blood-2010-12-325522DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The development and antigen-dependent differentiation of B lymphocytes are orchestrated by an array of growth factors, cytokines, and chemokines that require tight spatiotemporal regulation. Heparan sulfate proteoglycans specifically bind and regulate the bioavailability of soluble protein ligands, but their role in the immune system has remained largely unexplored. Modification of heparan sulfate by glucuronyl C5-epimerase (Glce) controls heparan sulfate-chain flexibility and thereby affects ligand binding. Here we show that Glce deficiency impairs B-cell maturation, resulting in decreased plasma cell numbers and immunoglobulin levels. We demonstrate that C5-epimerase modification of heparan sulfate is critical for binding of a proliferation inducing ligand (APRIL) and that Glce-deficient plasma cells fail to respond to APRIL-mediated survival signals. Our results identify heparan sulfate proteoglycans as novel players in B-cell maturation and differentiation and suggest that heparan sulfate conformation is crucial for recruitment of factors that control plasma cell survival.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Groen, Richard W. J. (author)
  • Kuil, Annemieke (author)
  • Weijer, Kees (author)
  • Kimberley, Fiona C. (author)
  • Medema, Jan Paul (author)
  • van Kuppevelt, Toin H. (author)
  • Li, Jin-PingUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)jinpili (author)
  • Spaargaren, Marcel (author)
  • Pals, Steven T. (author)
  • Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)

Related titles

  • In:Blood: American Society of Hematology117:23, s. 6162-61710006-49711528-0020

Internet link

Find in a library

  • Blood (Search for host publication in LIBRIS)

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view