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- Biglarnia, Ali-RezaUppsala universitet,Transplantationskirurgi (author)
Prompt reversal of a severe complement activation by eculizumab in a patient undergoing intentional ABO-incompatible pancreas and kidney transplantation
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- 2011-06-22
- Frontiers Media SA,2011
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-155664
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-155664URI
- https://doi.org/10.1111/j.1432-2277.2011.01290.xDOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- We describe the presumably first intentional ABO-incompatible deceased-donor kidney and pancreas transplantation with a severe antibody-mediated rejection during a rebound of isoagglutinins. Rejection was successfully treated with eculizumab, which inhibits the terminal pathway of complement. Complement analysis (C3, C3d,g, and a modified assay of classical complement-related hemolytic function) documented complement activation and confirmed that eculizumab completely blocked complement function. At 6 months, the patient had normal kidney and pancreas function, and histological evaluations revealed no evidence of sustained graft damage. This successful transplantation suggests that ABO barriers can safely be overcome without extensive preconditioning, when the complement inhibitor eculizumab is included.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- ABO-incompatible pancreas and kidney transplantation
- accommodation
- complement activation
- Eculizumab
- MEDICINE
- MEDICIN
- Pathology
- Patologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Nilsson, BoUppsala universitet,Klinisk immunologi(Swepub:uu)bonils (author)
- Nilsson, ThomasUppsala universitet,Institutionen för medicinska vetenskaper (author)
- von Zur-Mühlen, BengtUppsala universitet,Transplantationskirurgi(Swepub:uu)bengmuhl (author)
- Wagner, MichaelUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)micwa703 (author)
- Berne, ChristianUppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)chber255 (author)
- Wanders, AlkwinUppsala universitet,Molekylär och morfologisk patologi(Swepub:uu)alkwwand (author)
- Magnusson, AndersUppsala universitet,Enheten för radiologi(Swepub:uu)anmag679 (author)
- Tufveson, GunnarUppsala universitet,Transplantationskirurgi(Swepub:uu)gutuf839 (author)
- Uppsala universitetTransplantationskirurgi (creator_code:org_t)
Related titles
- In:Transplant International: Frontiers Media SA24:8, s. e61-e660934-08741432-2277
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